Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats

Disposition kinetics of imidocarb , an antiprotozoan drug, was studied in normal and febrile dog sand goats . Fever was induced using E. coli endotoxin , Trypanosoma evansi and Infectious Bovine Rhinotracheitis (I BR) virus.The objectives of the study were to compare the disposition kinetics of...

Full description

Saved in:

Bibliographic Details
Main Author:	Abdullah, Abdul Salam
Format:	Thesis
Language:	English English
Published:	1983
Subjects:	Veterinary drugs residues
Online Access:	http://psasir.upm.edu.my/id/eprint/11739/1/FPV_1983_7.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-upm-ir.11739
record_format	uketd_dc
spelling	my-upm-ir.117392024-06-25T08:51:27Z Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats 1983-09 Abdullah, Abdul Salam Disposition kinetics of imidocarb , an antiprotozoan drug, was studied in normal and febrile dog sand goats . Fever was induced using E. coli endotoxin , Trypanosoma evansi and Infectious Bovine Rhinotracheitis (I BR) virus.The objectives of the study were to compare the disposition kinetics of imidocarb in ruminant and monogastrics pecies , and the influence of fever of different etiology on the disposition kinetics of this drug. The concentration of imidocarb in body fluids and tissues were measured by spectrophotometry.The disposition kinetics of imidocarb in normal and febrile dogs and goats can be adequately described by a two-compartment open model. The apparent volume of the central compartment , V,c was significantly lower (P<0.01) but the volume of distribution, V d(area) was significantly higher (P<0.05) in normal goats than in dogs.Higher volume of distribution and the ratio of imidocarb level in peripheral- to-central compartment in goats ( 6:1 ) prolonged elimination of the drug, resulting in considerably higher levels of the drug still present in the tissues 14 days after a single subcutaneous or intramuscular dose. Veterinary drugs residues 1983-09 Thesis http://psasir.upm.edu.my/id/eprint/11739/ http://psasir.upm.edu.my/id/eprint/11739/1/FPV_1983_7.pdf text en public doctoral Universiti Pertanian Malaysia Veterinary drugs residues Faculty of Veterinary medicine Ayob, Ahmad Mahdzan English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
advisor	Ayob, Ahmad Mahdzan
topic	Veterinary drugs residues
spellingShingle	Veterinary drugs residues Abdullah, Abdul Salam Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
description	Disposition kinetics of imidocarb , an antiprotozoan drug, was studied in normal and febrile dog sand goats . Fever was induced using E. coli endotoxin , Trypanosoma evansi and Infectious Bovine Rhinotracheitis (I BR) virus.The objectives of the study were to compare the disposition kinetics of imidocarb in ruminant and monogastrics pecies , and the influence of fever of different etiology on the disposition kinetics of this drug. The concentration of imidocarb in body fluids and tissues were measured by spectrophotometry.The disposition kinetics of imidocarb in normal and febrile dogs and goats can be adequately described by a two-compartment open model. The apparent volume of the central compartment , V,c was significantly lower (P<0.01) but the volume of distribution, V d(area) was significantly higher (P<0.05) in normal goats than in dogs.Higher volume of distribution and the ratio of imidocarb level in peripheral- to-central compartment in goats ( 6:1 ) prolonged elimination of the drug, resulting in considerably higher levels of the drug still present in the tissues 14 days after a single subcutaneous or intramuscular dose.
format	Thesis
qualification_level	Doctorate
author	Abdullah, Abdul Salam
author_facet	Abdullah, Abdul Salam
author_sort	Abdullah, Abdul Salam
title	Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_short	Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_full	Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_fullStr	Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_full_unstemmed	Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats
title_sort	pharmacokinetics of imidocarb in normal and febrile dogs and goats
granting_institution	Universiti Pertanian Malaysia
granting_department	Faculty of Veterinary medicine
publishDate	1983
url	http://psasir.upm.edu.my/id/eprint/11739/1/FPV_1983_7.pdf
_version_	1804888652496502784

Pharmacokinetics Of Imidocarb In Normal And Febrile Dogs And Goats

Similar Items