The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels

The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels

Effects of selected herbs in delaying ageing in rats were studied by measuring the activity of plasma malondialdehyde (MDA) as an index of lipid peroxidation status. Likewise, the activities of anti-oxidative enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (G...

Full description

Saved in:
Bibliographic Details
Main Author: Ismail, Imilia
Format: Thesis
Language:English
Published: 2004
Subjects:
Online Access:http://psasir.upm.edu.my/id/eprint/45/1/1000548959_fpv_2004_20.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-upm-ir.45
record_format uketd_dc
spelling my-upm-ir.452015-08-06T02:06:22Z The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels 2004-12 Ismail, Imilia Effects of selected herbs in delaying ageing in rats were studied by measuring the activity of plasma malondialdehyde (MDA) as an index of lipid peroxidation status. Likewise, the activities of anti-oxidative enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were also assessed as indices of anti-oxidant. Descriptive histological changes in the brain, liver, kidney and heart were also performed, while, quantitative histology was determined by counting the necrotic cells and lipofuscin pigments in the liver, the glomeruli in the kidney, and the neuron cells in the brain. Fifty male Sprague-Dawley rats each of the 4-week and 10-month old respectively were used. All rats were divided equally into 10 groups. While the control group was given the basal diet, other groups were fed the basal diet containing 5% of Sireh (Piper betle; S), Bunga Kantan (Pheaomeria speciosa; BK), Dukong Anak (Phyllanthus niruri; DA) or Pucuk Gajus (Anacardium occidentale L.; PG). Blood 4 samples for biochemical analysis were taken every three weeks by intracardiac puncture. The results showed that at almost all instances, the concentration of MDA in the controls were significantly (p<0.05) higher than any other groups. The concentration of MDA was been markedly reduced by herbal supplementation. Likewise, supplementation had also exerted its protective effect against ageing by increasing the activity of anti-oxidant enzymes. Such effective scavenging mechanism in the herbal supplemented group had led to less ageing lesion development in these rats. In conclusion, the selected herbs especially those of DA and PG were able to alleviate ageing-induced injuries in rats via boosting the scavenging system or generating anti-oxidant-like compounds. 2004-12 Thesis http://psasir.upm.edu.my/id/eprint/45/ http://psasir.upm.edu.my/id/eprint/45/1/1000548959_fpv_2004_20.pdf application/pdf en public masters Universiti Putra Malaysia Faculty of Veterinary Medicine
institution Universiti Putra Malaysia
collection PSAS Institutional Repository
language English
topic


spellingShingle


Ismail, Imilia
The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
description Effects of selected herbs in delaying ageing in rats were studied by measuring the activity of plasma malondialdehyde (MDA) as an index of lipid peroxidation status. Likewise, the activities of anti-oxidative enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were also assessed as indices of anti-oxidant. Descriptive histological changes in the brain, liver, kidney and heart were also performed, while, quantitative histology was determined by counting the necrotic cells and lipofuscin pigments in the liver, the glomeruli in the kidney, and the neuron cells in the brain. Fifty male Sprague-Dawley rats each of the 4-week and 10-month old respectively were used. All rats were divided equally into 10 groups. While the control group was given the basal diet, other groups were fed the basal diet containing 5% of Sireh (Piper betle; S), Bunga Kantan (Pheaomeria speciosa; BK), Dukong Anak (Phyllanthus niruri; DA) or Pucuk Gajus (Anacardium occidentale L.; PG). Blood 4 samples for biochemical analysis were taken every three weeks by intracardiac puncture. The results showed that at almost all instances, the concentration of MDA in the controls were significantly (p<0.05) higher than any other groups. The concentration of MDA was been markedly reduced by herbal supplementation. Likewise, supplementation had also exerted its protective effect against ageing by increasing the activity of anti-oxidant enzymes. Such effective scavenging mechanism in the herbal supplemented group had led to less ageing lesion development in these rats. In conclusion, the selected herbs especially those of DA and PG were able to alleviate ageing-induced injuries in rats via boosting the scavenging system or generating anti-oxidant-like compounds.
format Thesis
qualification_level Master's degree
author Ismail, Imilia
author_facet Ismail, Imilia
author_sort Ismail, Imilia
title The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_short The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_full The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_fullStr The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_full_unstemmed The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_sort efficacy of selected herbs in delaying the ageing process as indicated by the reduction in plasma malondialdehyde levels
granting_institution Universiti Putra Malaysia
granting_department Faculty of Veterinary Medicine
publishDate 2004
url http://psasir.upm.edu.my/id/eprint/45/1/1000548959_fpv_2004_20.pdf
_version_ 1747810155028807680

Similar Items