Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia

Prevention of osteoporotic fracture requires identification of individuals at high risk with WHO fracture risk assessment tool (FRAX®) commonly used to estimate fracture probability despite some inadequate predictive discrimination ability. Procollagen-type-1 amino-terminal propeptide (P1NP) and car...

Full description

Saved in:

Bibliographic Details
Main Author:	Shahifar, Nasrin
Format:	Thesis
Language:	English
Published:	2019
Subjects:	Osteoporosis Bones - Aging
Online Access:	http://psasir.upm.edu.my/id/eprint/85549/1/FPSK%28M%29%202019%2039%20IR.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-upm-ir.85549
record_format	uketd_dc
spelling	my-upm-ir.855492021-09-01T00:24:34Z Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia 2019-04 Shahifar, Nasrin Prevention of osteoporotic fracture requires identification of individuals at high risk with WHO fracture risk assessment tool (FRAX®) commonly used to estimate fracture probability despite some inadequate predictive discrimination ability. Procollagen-type-1 amino-terminal propeptide (P1NP) and carboxy-terminal-collagen crosslinks (CTX), the current bone turnover markers (BTM) and sphingosine-1-phosphate (S1P), a novel marker of bone metabolism may complement the current model. This study aimed to determine the association of P1NP, CTX, and S1P with sociodemographic factors, clinical characteristics, bone mineral density (BMD) and blood tests for bone profile among Chinese adults in Puchong and Kajang, Malaysia. This was a cross-sectional study involving Chinese subjects aged between 50 to 90 years old in Puchong and Kajang who attended a health screening program in Puchong Specialist Centre from December 2015 to December 2017. Each subject had a BMD determined by a dual-energy x-ray absorptiometry (DXA) at lumbar spine, femoral neck, total hip and total body. 10 ml of fasting blood sample were taken and analysed for 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (iPTH), calcium, phosphate, P1NP, CTX and S1P. Pearson’s and Spearman’s correlation tests were used to determine the associations between P1NP, CTX and S1P with sociodemographics, clinical characteristics, BMD and bone profile. All analyses were stratified by gender and BMD categories (normal BMD, osteopenia and osteoporosis). A total of 131 subjects [45 (34.4%) males and 86 (65.6%) post-menopausal women] with a median age of 65 (IQR=17) years old were recruited. Osteopenia and osteoporosis were diagnosed in 46.6% and 29.0% of subjects, respectively. P1NP and CTX were significantly higher in post-menopausal women (P1NP=61.71ng/ml, CTX=0.489 ng/ml) compared to men (P1NP=46.94 ng/ml, CTX=0.381 ng/ml). Both BTM differed significantly according to BMD categories (p<0.001) with values highest in osteoporosis and lowest in normal BMD. However, there is no difference in S1P levels in men (2.12 ± 0.75 μmol/L) and post-menopausal women (1.96 ± 0.68 μmol/L) did not differ significantly (p=0.235) and did not differ according to BMD categories (p=0.457). S1P did not correlate with any individual BMD measurements nor with P1NP or CTX in both males and females. In post-menopausal women, CTX and P1NP significantly negatively correlated with BMD measurements at all sites except femoral neck. In men, CTX significantly negatively correlated with femoral neck (r=-0.360, p=0.015) and total hip (r=-0.456, p=0.002) whilst P1NP only with total body (r=-0.344, p=0.021). Osteoporosis was diagnosed in 29% of subjects. P1NP and CTX were significantly higher in post-menopausal women compared to men as well as significantly differed between osteoporosis, oeteopenia and normal BMD. In post-menopausal women, P1NP and CTX negatively correlated with all BMD sites measurements except for femoral neck. In men, P1NP only negatively correlated with total body whilst CTX only with femoral neck and total hip. In contrast, S1P did not differ according to BMD characteristics nor gender and not associated with any BMD sites measurement. Thus, in this group of Malaysian Chinese subjects, the current BTM reflects bone loss better than S1P, especially in females. Osteoporosis Bones - Aging 2019-04 Thesis http://psasir.upm.edu.my/id/eprint/85549/ http://psasir.upm.edu.my/id/eprint/85549/1/FPSK%28M%29%202019%2039%20IR.pdf text en public masters Universiti Putra Malaysia Osteoporosis Bones - Aging Samsudin, Intan Nureslyna
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
advisor	Samsudin, Intan Nureslyna
topic	Osteoporosis Bones - Aging
spellingShingle	Osteoporosis Bones - Aging Shahifar, Nasrin Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia
description	Prevention of osteoporotic fracture requires identification of individuals at high risk with WHO fracture risk assessment tool (FRAX®) commonly used to estimate fracture probability despite some inadequate predictive discrimination ability. Procollagen-type-1 amino-terminal propeptide (P1NP) and carboxy-terminal-collagen crosslinks (CTX), the current bone turnover markers (BTM) and sphingosine-1-phosphate (S1P), a novel marker of bone metabolism may complement the current model. This study aimed to determine the association of P1NP, CTX, and S1P with sociodemographic factors, clinical characteristics, bone mineral density (BMD) and blood tests for bone profile among Chinese adults in Puchong and Kajang, Malaysia. This was a cross-sectional study involving Chinese subjects aged between 50 to 90 years old in Puchong and Kajang who attended a health screening program in Puchong Specialist Centre from December 2015 to December 2017. Each subject had a BMD determined by a dual-energy x-ray absorptiometry (DXA) at lumbar spine, femoral neck, total hip and total body. 10 ml of fasting blood sample were taken and analysed for 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (iPTH), calcium, phosphate, P1NP, CTX and S1P. Pearson’s and Spearman’s correlation tests were used to determine the associations between P1NP, CTX and S1P with sociodemographics, clinical characteristics, BMD and bone profile. All analyses were stratified by gender and BMD categories (normal BMD, osteopenia and osteoporosis). A total of 131 subjects [45 (34.4%) males and 86 (65.6%) post-menopausal women] with a median age of 65 (IQR=17) years old were recruited. Osteopenia and osteoporosis were diagnosed in 46.6% and 29.0% of subjects, respectively. P1NP and CTX were significantly higher in post-menopausal women (P1NP=61.71ng/ml, CTX=0.489 ng/ml) compared to men (P1NP=46.94 ng/ml, CTX=0.381 ng/ml). Both BTM differed significantly according to BMD categories (p<0.001) with values highest in osteoporosis and lowest in normal BMD. However, there is no difference in S1P levels in men (2.12 ± 0.75 μmol/L) and post-menopausal women (1.96 ± 0.68 μmol/L) did not differ significantly (p=0.235) and did not differ according to BMD categories (p=0.457). S1P did not correlate with any individual BMD measurements nor with P1NP or CTX in both males and females. In post-menopausal women, CTX and P1NP significantly negatively correlated with BMD measurements at all sites except femoral neck. In men, CTX significantly negatively correlated with femoral neck (r=-0.360, p=0.015) and total hip (r=-0.456, p=0.002) whilst P1NP only with total body (r=-0.344, p=0.021). Osteoporosis was diagnosed in 29% of subjects. P1NP and CTX were significantly higher in post-menopausal women compared to men as well as significantly differed between osteoporosis, oeteopenia and normal BMD. In post-menopausal women, P1NP and CTX negatively correlated with all BMD sites measurements except for femoral neck. In men, P1NP only negatively correlated with total body whilst CTX only with femoral neck and total hip. In contrast, S1P did not differ according to BMD characteristics nor gender and not associated with any BMD sites measurement. Thus, in this group of Malaysian Chinese subjects, the current BTM reflects bone loss better than S1P, especially in females.
format	Thesis
qualification_level	Master's degree
author	Shahifar, Nasrin
author_facet	Shahifar, Nasrin
author_sort	Shahifar, Nasrin
title	Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia
title_short	Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia
title_full	Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia
title_fullStr	Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia
title_full_unstemmed	Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia
title_sort	bone turnover markers (p1np, ctx) and sphingosine-1- phosphate (s1p) in determining bone health among chinese adult residents of puchong and kajang in selangor, malaysia
granting_institution	Universiti Putra Malaysia
publishDate	2019
url	http://psasir.upm.edu.my/id/eprint/85549/1/FPSK%28M%29%202019%2039%20IR.pdf
_version_	1747813558295461888

Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia

Similar Items