Studies on coordination chemistry and bioactivity of complexes of Ni(II) and Cu(II) containing some nitrogen-sulphur donor ligands
Several Schiff bases of S-benzyldithiocarbazate (SBDTC) and Smethyldithiocarbazate (SMDTC) have been synthesised. Complexes of NiCll) and Cu(IT) were prepared. These compounds were characterised by elemental analyses and various physico-chemical techniques. The Schiff bases and their metal comple...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2001
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/9300/1/FSAS_2001_37_A.pdf |
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| Summary: | Several Schiff bases of S-benzyldithiocarbazate (SBDTC) and Smethyldithiocarbazate
(SMDTC) have been synthesised. Complexes of NiCll) and
Cu(IT) were prepared. These compounds were characterised by elemental analyses and
various physico-chemical techniques. The Schiff bases and their metal complexes were
tested to evaluate their cytotoxic, antimicrobial and antioxidant activities. Cytotoxic
screening was carried out against the T-Iymphoblastic leukemic cells (CEM-SS) and
colon cancer cells (HT-29). Antimicrobial screening was carried out against four
bacteria and four fungi. The nickelCTI) complexes are four- and five- coordinated while
the copper(TI) complex is five-coordinated. |
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