Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications

Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications

Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone. In spite of the availability of mass vaccination programmes, these sporadic outbreaks are believed to be th...

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Main Author: Thurai Raja, Priadarishni Ramanujam
Format: Thesis
Language:English
English
Published: 2003
Subjects:
Newcastle Disease Virus - Malaysia.
Peptides - Malaysia.
Online Access:http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf
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id my-upm-ir.9534
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spelling my-upm-ir.95342012-08-27T06:48:59Z Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications 2003-01 Thurai Raja, Priadarishni Ramanujam Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone. In spite of the availability of mass vaccination programmes, these sporadic outbreaks are believed to be the result of malpractice in backyard farming. The mechanism of NOV infection is still not clearly understood, making it difficult to validate any effective drug candidates. Bearing this in mind, a phage display random peptide library was used to identify peptide ligands that interact with NOV. A phage carrying the TLTTKLY sequence represented 97% of the total phage screened from the third round of biopanning against NOV strain AF2240. This phage was characterized and both cyclic and linear synthetic peptides bearing the homologous sequence were synthesized. Newcastle Disease Virus - Malaysia. Peptides - Malaysia. 2003-01 Thesis http://psasir.upm.edu.my/id/eprint/9534/ http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf application/pdf en public phd doctoral Universiti Putra Malaysia Newcastle Disease Virus - Malaysia. Peptides - Malaysia. Faculty of Science and Environmental Studies English
institution Universiti Putra Malaysia
collection PSAS Institutional Repository
language English
English
topic Newcastle Disease Virus - Malaysia.
Peptides - Malaysia.
spellingShingle Newcastle Disease Virus - Malaysia.
Peptides - Malaysia.

Thurai Raja, Priadarishni Ramanujam
Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
description Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone. In spite of the availability of mass vaccination programmes, these sporadic outbreaks are believed to be the result of malpractice in backyard farming. The mechanism of NOV infection is still not clearly understood, making it difficult to validate any effective drug candidates. Bearing this in mind, a phage display random peptide library was used to identify peptide ligands that interact with NOV. A phage carrying the TLTTKLY sequence represented 97% of the total phage screened from the third round of biopanning against NOV strain AF2240. This phage was characterized and both cyclic and linear synthetic peptides bearing the homologous sequence were synthesized.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Thurai Raja, Priadarishni Ramanujam
author_facet Thurai Raja, Priadarishni Ramanujam
author_sort Thurai Raja, Priadarishni Ramanujam
title Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
title_short Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
title_full Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
title_fullStr Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
title_full_unstemmed Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
title_sort peptide ligands that interact with newcastle disease virus: selection, characterization and applications
granting_institution Universiti Putra Malaysia
granting_department Faculty of Science and Environmental Studies
publishDate 2003
url http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf
_version_ 1747810975647531008

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