Chemical Constituents and Biological Activities of Micromelum Minutum (Rutaceae) and Two Eugenia Species (Myrtaceae)
Drug discovery has been a goal of mankind since prehistoric times. Plants continue to be an exceptionally viable source of biologically active natural products. However, only small portion of the higher plants has been phytochemically and pharmacologically investigated. Two separate collections...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2003
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/9560/1/FSAS_2003_20_A.pdf |
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| Summary: | Drug discovery has been a goal of mankind since prehistoric times. Plants
continue to be an exceptionally viable source of biologically active natural
products. However, only small portion of the higher plants has been
phytochemically and pharmacologically investigated.
Two separate collections of Micromelum minutum from Sabah and two
Eugenia species, E. chlorantha and E. cumingiana collected from the northern
forest of Perak were subjected to phytochemical investigation with the isolation of
a number of compounds. The structures of these compounds were elucidated by
using spectroscopic methods such as IR, UV, NMR, MS and also by comparison
with previous reports. The crude extracts, essential oil and isolated compounds from these plant materials were evaluated for their antiinflammatory, cytotoxic
and antimicrobial activities using carrageenan-induced rat paw oedema, MTT and
disc diffusion methods, respectively. Some isolated compounds showed
interesting biological activities. |
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