Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones

Kajian ini dimulakan dengan sintesis dan pencirian dua siri utama bahan pemula: pengalkilan naftaldehid (2-8) dan pengasetilan kumarin tertukar ganti (9-11). Bahan pemula yang diperoleh dikenalpasti melalui kaedah spektroskopi seperti inframerah transformasi Fourier (FTIR), resonans magnet nukleus (...

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Main Author:	Lim , Sumithda Yeong Hui
Format:	Thesis
Language:	English
Published:	2016
Subjects:	QC1 Physics (General)
Online Access:	http://eprints.usm.my/31375/1/SUMITHDA_LIM_YEONG_HUI_24.pdf
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spelling	my-usm-ep.313752019-04-12T05:25:23Z Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones 2016-03 Lim , Sumithda Yeong Hui QC1 Physics (General) Kajian ini dimulakan dengan sintesis dan pencirian dua siri utama bahan pemula: pengalkilan naftaldehid (2-8) dan pengasetilan kumarin tertukar ganti (9-11). Bahan pemula yang diperoleh dikenalpasti melalui kaedah spektroskopi seperti inframerah transformasi Fourier (FTIR), resonans magnet nukleus (NMR) dan mikroanalisis CHN. Analisa pembelauan sinar-X hablur tunggal (XRD) juga dijalankan dengan hablur bagi sebatian 3, 34, dan 41 menghablur dalam sistem kristal triklinik. Lima siri kalkon kemudiannya disintesis melalui kaedah kondensasi Claisen-Schmidt dengan tiga siri diterbitkan daripada kumarin asetil tertukar ganti (12-33) dan dua siri yang lain diterbitkan daripada asetofenon tertukar ganti (34-46). Semua kalkon yang disintesis telah dicirikan dengan analisa unsur (CHN), spektroskopi FTIR , 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC dan 1H-13C HMBC. Kalkon 23, 28, 34, dan 41 telah dipilih untuk analisis kristolografi. This study was started by the synthesis and characterization of two main series of starting materials: alkylation of naphthaldehydes (2-8) and acetylation of substituted coumarins (9-11). The starting materials thus obtained were elucidated by the spectroscopic methods such as fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and CHN microanalyses. Single crystal X-ray diffraction (XRD) analyses have also been carried out wherein the crystals of compound 3, 34 and 41 crystallized in a triclinic crystal system. Five novel series of chalcones were subsequently synthesized by means of Claisen-Schmidt condensation wherein three series were derived from substituted acetyl coumarins (12-33) and the remaining two series was derived from substituted acetophenones (34-46). All the synthesized chalcones were characterized by elemental analysis (CHN), FTIR, 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC and 1H-13C HMBC spectroscopy. Selected chalcones, 23, 28, 34, and 41 were selected for crystallography analysis. 2016-03 Thesis http://eprints.usm.my/31375/ http://eprints.usm.my/31375/1/SUMITHDA_LIM_YEONG_HUI_24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Fizik (School of Physics)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QC1 Physics (General)
spellingShingle	QC1 Physics (General) Lim , Sumithda Yeong Hui Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones
description	Kajian ini dimulakan dengan sintesis dan pencirian dua siri utama bahan pemula: pengalkilan naftaldehid (2-8) dan pengasetilan kumarin tertukar ganti (9-11). Bahan pemula yang diperoleh dikenalpasti melalui kaedah spektroskopi seperti inframerah transformasi Fourier (FTIR), resonans magnet nukleus (NMR) dan mikroanalisis CHN. Analisa pembelauan sinar-X hablur tunggal (XRD) juga dijalankan dengan hablur bagi sebatian 3, 34, dan 41 menghablur dalam sistem kristal triklinik. Lima siri kalkon kemudiannya disintesis melalui kaedah kondensasi Claisen-Schmidt dengan tiga siri diterbitkan daripada kumarin asetil tertukar ganti (12-33) dan dua siri yang lain diterbitkan daripada asetofenon tertukar ganti (34-46). Semua kalkon yang disintesis telah dicirikan dengan analisa unsur (CHN), spektroskopi FTIR , 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC dan 1H-13C HMBC. Kalkon 23, 28, 34, dan 41 telah dipilih untuk analisis kristolografi. This study was started by the synthesis and characterization of two main series of starting materials: alkylation of naphthaldehydes (2-8) and acetylation of substituted coumarins (9-11). The starting materials thus obtained were elucidated by the spectroscopic methods such as fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and CHN microanalyses. Single crystal X-ray diffraction (XRD) analyses have also been carried out wherein the crystals of compound 3, 34 and 41 crystallized in a triclinic crystal system. Five novel series of chalcones were subsequently synthesized by means of Claisen-Schmidt condensation wherein three series were derived from substituted acetyl coumarins (12-33) and the remaining two series was derived from substituted acetophenones (34-46). All the synthesized chalcones were characterized by elemental analysis (CHN), FTIR, 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC and 1H-13C HMBC spectroscopy. Selected chalcones, 23, 28, 34, and 41 were selected for crystallography analysis.
format	Thesis
qualification_level	Master's degree
author	Lim , Sumithda Yeong Hui
author_facet	Lim , Sumithda Yeong Hui
author_sort	Lim , Sumithda Yeong Hui
title	Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones
title_short	Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones
title_full	Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones
title_fullStr	Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones
title_full_unstemmed	Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones
title_sort	synthesis, characterization and biological evaluation of naphthalene - and coumarin-based chalcones
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Fizik (School of Physics)
publishDate	2016
url	http://eprints.usm.my/31375/1/SUMITHDA_LIM_YEONG_HUI_24.pdf
_version_	1747820411217772544

Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones

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