Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats

Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats

Labisia pumi/a var. a/ata (LPA) atau Kacip Fatimah disenaraikan sebagai salah satu spesis utama oleh kerajaan Malaysia untuk dijalankan kajian saintifik pelbagai disiplin ke arah pembangunan ubatan herba tempatan berasaskan bukti saintifik. Kajian yang dihuraikan di dalam tesis ini adalah sebahag...

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Main Author: Mohd Puad @ Mohd Fuad, Wan Ezumi
Format: Thesis
Language:English
Published: 2009
Subjects:
R735-854 Medical education
Medical schools
Research
Online Access:http://eprints.usm.my/31421/1/WAN_EZUMI_BINTI_MOHD_PUAD_%40_MOHD_FUAD.pdf
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spelling my-usm-ep.314212017-05-15T04:43:29Z Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats 2009-10 Mohd Puad @ Mohd Fuad, Wan Ezumi R735-854 Medical education. Medical schools. Research Labisia pumi/a var. a/ata (LPA) atau Kacip Fatimah disenaraikan sebagai salah satu spesis utama oleh kerajaan Malaysia untuk dijalankan kajian saintifik pelbagai disiplin ke arah pembangunan ubatan herba tempatan berasaskan bukti saintifik. Kajian yang dihuraikan di dalam tesis ini adalah sebahagian daripada kajian pra klinikal ke atas LPA untuk menilai profil keselamatannya. Tujuan kajian ini adalah untuk menentukan potensi kesan sediaan komersial ekstrak air LPA ke atas ketoksikan reproduktif dan pertumbuhan pada tikus betina Sprague Dawley. Kajian permulaan dijalankan dengan menggunakan ekstrak air tidak terpiawai LPA pada dos 2, 20, 200 dan 400 mg/kg/hari. Sediaan komersial ekstrak air terpiawai LPA, didaftarkan sebagai Biolabisia® pad a dos 2, 20, 200, 400, 1000 mg/kg/hari atau air suling (kawalan) diberikan kepada tikus secara gavaging dalam kajian utama. Kajian Teratogenik dijalankan dengan memberikan rawatan Biolabisia® kepada tikus hamil semasa peringkat organogenesis. Rawatan ke atas tikus diberi sejak sebelum tempoh mengawan sehingga hari ke-7 waktu laktasi dalam kajian Ketoksikan reproduktif dan sebelum mengawan sehingga hari ke-15 kehamilan bagi kajian Kesuburan. Labisia pumi/a var, a/ala (LPA) or Kacip Fatimah has been listed by the government of Malaysia as one of the priority species for a multi-disciplinary scientific study towards the development of scientific, evidence-based herbal medicine. The present study described in this thesis is part of the preclinical assessment of LPA to evaluate its safety profile. The aims of this study were to evaluate the potential effects of aqueous extract of LPA on reproductive and developmental toxicities in Sprague Dawley rats. A preliminary study was conducted using unstandardised extract of LPA at 2, 20, 200 and 400 mg/kg/day. Commercially prepared standard aqueous extract of LPA, registered as Biolabisia® at the doses of 2,20, 200,400, 1000 mg/kg/day or distilled water (control) were administered by gavaging to animals during the main studies. The Teratogenic study was conducted by treating pregnant animals with Biolabisia® during the period of organogenesis. Treatments of animals began from the time prior to mating until lactational periods of seven days in the Reproductive toxicity study and from before mating up to day 15 of pregnancy in the Fertility study. 2009-10 Thesis http://eprints.usm.my/31421/ http://eprints.usm.my/31421/1/WAN_EZUMI_BINTI_MOHD_PUAD_%40_MOHD_FUAD.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R735-854 Medical education
Medical schools
Research
spellingShingle R735-854 Medical education
Medical schools
Research
Mohd Puad @ Mohd Fuad, Wan Ezumi
Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats
description Labisia pumi/a var. a/ata (LPA) atau Kacip Fatimah disenaraikan sebagai salah satu spesis utama oleh kerajaan Malaysia untuk dijalankan kajian saintifik pelbagai disiplin ke arah pembangunan ubatan herba tempatan berasaskan bukti saintifik. Kajian yang dihuraikan di dalam tesis ini adalah sebahagian daripada kajian pra klinikal ke atas LPA untuk menilai profil keselamatannya. Tujuan kajian ini adalah untuk menentukan potensi kesan sediaan komersial ekstrak air LPA ke atas ketoksikan reproduktif dan pertumbuhan pada tikus betina Sprague Dawley. Kajian permulaan dijalankan dengan menggunakan ekstrak air tidak terpiawai LPA pada dos 2, 20, 200 dan 400 mg/kg/hari. Sediaan komersial ekstrak air terpiawai LPA, didaftarkan sebagai Biolabisia® pad a dos 2, 20, 200, 400, 1000 mg/kg/hari atau air suling (kawalan) diberikan kepada tikus secara gavaging dalam kajian utama. Kajian Teratogenik dijalankan dengan memberikan rawatan Biolabisia® kepada tikus hamil semasa peringkat organogenesis. Rawatan ke atas tikus diberi sejak sebelum tempoh mengawan sehingga hari ke-7 waktu laktasi dalam kajian Ketoksikan reproduktif dan sebelum mengawan sehingga hari ke-15 kehamilan bagi kajian Kesuburan. Labisia pumi/a var, a/ala (LPA) or Kacip Fatimah has been listed by the government of Malaysia as one of the priority species for a multi-disciplinary scientific study towards the development of scientific, evidence-based herbal medicine. The present study described in this thesis is part of the preclinical assessment of LPA to evaluate its safety profile. The aims of this study were to evaluate the potential effects of aqueous extract of LPA on reproductive and developmental toxicities in Sprague Dawley rats. A preliminary study was conducted using unstandardised extract of LPA at 2, 20, 200 and 400 mg/kg/day. Commercially prepared standard aqueous extract of LPA, registered as Biolabisia® at the doses of 2,20, 200,400, 1000 mg/kg/day or distilled water (control) were administered by gavaging to animals during the main studies. The Teratogenic study was conducted by treating pregnant animals with Biolabisia® during the period of organogenesis. Treatments of animals began from the time prior to mating until lactational periods of seven days in the Reproductive toxicity study and from before mating up to day 15 of pregnancy in the Fertility study.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Mohd Puad @ Mohd Fuad, Wan Ezumi
author_facet Mohd Puad @ Mohd Fuad, Wan Ezumi
author_sort Mohd Puad @ Mohd Fuad, Wan Ezumi
title Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats
title_short Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats
title_full Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats
title_fullStr Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats
title_full_unstemmed Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats
title_sort evaluation of the reproductive and developmental toxicities of the aqueous extract of labisia pumila var. alata in female rats
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2009
url http://eprints.usm.my/31421/1/WAN_EZUMI_BINTI_MOHD_PUAD_%40_MOHD_FUAD.pdf
_version_ 1747820420499767296

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