Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase

Dalam kajian ini, kesan antiobesiti Orthosiphon stamineus (OS) disiasat menggunakan ekstrak etanol (ET), ekstrak 50% air-etanol (EW) dan ekstrak air (W) daripada tumbuhan ini. Ekstrak yang mempunyai aktiviti antiangiogenik paling tinggi, iaitu ET telah menunjukkan kesan antiobesiti secara in vivo. W...

Full description

Saved in:

Bibliographic Details
Main Author:	Hashim, Suzana
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/31646/1/SUZANA_BINTI_HASHIM_24.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.31646
record_format	uketd_dc
spelling	my-usm-ep.316462019-04-12T05:25:26Z Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase 2016-02 Hashim, Suzana RS1-441 Pharmacy and materia medica Dalam kajian ini, kesan antiobesiti Orthosiphon stamineus (OS) disiasat menggunakan ekstrak etanol (ET), ekstrak 50% air-etanol (EW) dan ekstrak air (W) daripada tumbuhan ini. Ekstrak yang mempunyai aktiviti antiangiogenik paling tinggi, iaitu ET telah menunjukkan kesan antiobesiti secara in vivo. Walau bagaimanapun, aktiviti ke atas enzim lipase pankreas adalah sederhana dengan ekstrak ET menunjukkan aktiviti yang paling tinggi diikuti oleh ekstrak EW dan W. Kesan menghalang percambahan sel preadipocyte (3T3-L1) turut diperhatikan dan ekstrak ET menunjukkan aktiviti paling kuat diikuti oleh ekstrak EW dan W. Aktiviti antiangiogenik dan profil kimia OS juga dikaji yang melibatkan sampel daripada lima lokasi berbeza diseluruh Semenanjung Malaysia iaitu Batu Kurau (BK), Kepala Batas (KB), Sik Kedah (S), Changkat Jering (CJ) dan Sungai Buloh (SB). In this study, the antiobesity effect of Orthosiphon stamineus (OS) was investigated using ethanol extract (ET), 50% ethanol-water extract (EW) and water extract (W) of this plant species. Ethanol extract with the most potent antiangiogenic activity showed a significant antiobesity property in vivo. However, the activity towards the pancreatic lipase enzyme was modest with ET being the most potent followed by EW and W in decreasing order of reactivity. Activity towards inhibition of preadipocyte cell proliferation (3T3-L1) was also observed with ET being the most potent followed by EW and W. The antiangiogenic activity and chemical profile of OS collected from five different locations throughout peninsular Malaysia was also studied namely Batu Kurau (BK), Kepala Batas (KB), Sik Kedah (S), Changkat Jering (CJ) and Sungai Buloh (SB). 2016-02 Thesis http://eprints.usm.my/31646/ http://eprints.usm.my/31646/1/SUZANA_BINTI_HASHIM_24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmaceutical Sciences)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Hashim, Suzana Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase
description	Dalam kajian ini, kesan antiobesiti Orthosiphon stamineus (OS) disiasat menggunakan ekstrak etanol (ET), ekstrak 50% air-etanol (EW) dan ekstrak air (W) daripada tumbuhan ini. Ekstrak yang mempunyai aktiviti antiangiogenik paling tinggi, iaitu ET telah menunjukkan kesan antiobesiti secara in vivo. Walau bagaimanapun, aktiviti ke atas enzim lipase pankreas adalah sederhana dengan ekstrak ET menunjukkan aktiviti yang paling tinggi diikuti oleh ekstrak EW dan W. Kesan menghalang percambahan sel preadipocyte (3T3-L1) turut diperhatikan dan ekstrak ET menunjukkan aktiviti paling kuat diikuti oleh ekstrak EW dan W. Aktiviti antiangiogenik dan profil kimia OS juga dikaji yang melibatkan sampel daripada lima lokasi berbeza diseluruh Semenanjung Malaysia iaitu Batu Kurau (BK), Kepala Batas (KB), Sik Kedah (S), Changkat Jering (CJ) dan Sungai Buloh (SB). In this study, the antiobesity effect of Orthosiphon stamineus (OS) was investigated using ethanol extract (ET), 50% ethanol-water extract (EW) and water extract (W) of this plant species. Ethanol extract with the most potent antiangiogenic activity showed a significant antiobesity property in vivo. However, the activity towards the pancreatic lipase enzyme was modest with ET being the most potent followed by EW and W in decreasing order of reactivity. Activity towards inhibition of preadipocyte cell proliferation (3T3-L1) was also observed with ET being the most potent followed by EW and W. The antiangiogenic activity and chemical profile of OS collected from five different locations throughout peninsular Malaysia was also studied namely Batu Kurau (BK), Kepala Batas (KB), Sik Kedah (S), Changkat Jering (CJ) and Sungai Buloh (SB).
format	Thesis
qualification_level	Master's degree
author	Hashim, Suzana
author_facet	Hashim, Suzana
author_sort	Hashim, Suzana
title	Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase
title_short	Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase
title_full	Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase
title_fullStr	Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase
title_full_unstemmed	Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase
title_sort	ethanol extract of orthosiphon stamineus benth. exhibits antiobesity effect by inhibiting angiogenesis and pancreatic lipase
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi (School of Pharmaceutical Sciences)
publishDate	2016
url	http://eprints.usm.my/31646/1/SUZANA_BINTI_HASHIM_24.pdf
_version_	1747820470909009920

Ethanol Extract Of Orthosiphon Stamineus Benth. Exhibits Antiobesity Effect By Inhibiting Angiogenesis And Pancreatic Lipase

Similar Items