Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action

Averrhoa carambola, biasanya dikenali sebagai belimbing merupakan salah satu herba yang digunakan secara meluas dalam perubatan tradisional masyarakat Malaysia, daun dan buahnya merupakan bahagian yang paling banyak digunakan. Kajian ini bertujuan menyiasat kesan antihiperlipidemik, aktiviti anti-ok...

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Main Author:	Sultan Ayesh, Mohammed Saghir
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/32289/1/SULTAN_AYESH_MOHAMMED_SAGHIR_24%28NN%29.pdf
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id	my-usm-ep.32289
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spelling	my-usm-ep.322892019-04-12T05:25:37Z Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action 2015-10 Sultan Ayesh, Mohammed Saghir RS1-441 Pharmacy and materia medica Averrhoa carambola, biasanya dikenali sebagai belimbing merupakan salah satu herba yang digunakan secara meluas dalam perubatan tradisional masyarakat Malaysia, daun dan buahnya merupakan bahagian yang paling banyak digunakan. Kajian ini bertujuan menyiasat kesan antihiperlipidemik, aktiviti anti-oksidan dan toksisiti ekstrak metanol dan akueus bahagian yang berlainan daripada A. carambola dengan tumpuan untuk elusidasi mekanisme tindakannya. Daripada semua ekstrak yang diuji, ekstrak metanol bahagian daun A. carambola menunjukkan aktiviti antihiperlipidemik terbaik dalam model tikus hiperlipidemik akut teraruh oleh poloxamer-407 berbanding kawalan hiperlipidemik yang setanding dengan aktiviti atorvastatin. Berikutan pemberian kronik sehingga lima minggu, tiada penurunan signifikan diperhatikan dalam aras parameter lipid bagi tikus normal yang dirawat dengan 1000 mg/kg ekstrak metanol daun. Sebaliknya, perbezaan yang signifikan diperhatikan dalam parameter lipid tikus hiperlipidemik teraruh diet tinggi lemak selepas dirawat dengan 500 dan 1000 mg/kg ekstrak metanol daun berbanding kawalan normal. Averrhoa carambola, commonly known as star fruit is one of the widely used herbs in the Malaysian traditional medicine, with the leaf and fruits being the most utilized parts. This study aims to investigate the antihyperlipidaemic effect, antioxidant activity and toxicity of methanolic and aqueous extracts of different parts of A. carambola with focus on elucidating the underlying mechanism of action. Of the tested extracts, the methanolic extract of A. carambola leaf showed the most potent antihyperlipidaemic activity in poloxamer-407-induced acute hyperlipidaemic rat model compared to the hyperlipidaemic control, which was comparable with that of atorvastatin. Upon chronic administration up to five weeks, no significant decrease was observed in the levels of the lipid parameters of normal rats treated with 1000 mg/kg of methanolic extract of leaf. In contrast, significant changes were observed in lipid parameters of high-fat diet induced hyperlipidemic rats after treated with 500 and 1000 mg/kg leaf methanolic extract as compared with the hyperlipidaemic control. 2015-10 Thesis http://eprints.usm.my/32289/ http://eprints.usm.my/32289/1/SULTAN_AYESH_MOHAMMED_SAGHIR_24%28NN%29.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmaceutical Sciences)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Sultan Ayesh, Mohammed Saghir Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
description	Averrhoa carambola, biasanya dikenali sebagai belimbing merupakan salah satu herba yang digunakan secara meluas dalam perubatan tradisional masyarakat Malaysia, daun dan buahnya merupakan bahagian yang paling banyak digunakan. Kajian ini bertujuan menyiasat kesan antihiperlipidemik, aktiviti anti-oksidan dan toksisiti ekstrak metanol dan akueus bahagian yang berlainan daripada A. carambola dengan tumpuan untuk elusidasi mekanisme tindakannya. Daripada semua ekstrak yang diuji, ekstrak metanol bahagian daun A. carambola menunjukkan aktiviti antihiperlipidemik terbaik dalam model tikus hiperlipidemik akut teraruh oleh poloxamer-407 berbanding kawalan hiperlipidemik yang setanding dengan aktiviti atorvastatin. Berikutan pemberian kronik sehingga lima minggu, tiada penurunan signifikan diperhatikan dalam aras parameter lipid bagi tikus normal yang dirawat dengan 1000 mg/kg ekstrak metanol daun. Sebaliknya, perbezaan yang signifikan diperhatikan dalam parameter lipid tikus hiperlipidemik teraruh diet tinggi lemak selepas dirawat dengan 500 dan 1000 mg/kg ekstrak metanol daun berbanding kawalan normal. Averrhoa carambola, commonly known as star fruit is one of the widely used herbs in the Malaysian traditional medicine, with the leaf and fruits being the most utilized parts. This study aims to investigate the antihyperlipidaemic effect, antioxidant activity and toxicity of methanolic and aqueous extracts of different parts of A. carambola with focus on elucidating the underlying mechanism of action. Of the tested extracts, the methanolic extract of A. carambola leaf showed the most potent antihyperlipidaemic activity in poloxamer-407-induced acute hyperlipidaemic rat model compared to the hyperlipidaemic control, which was comparable with that of atorvastatin. Upon chronic administration up to five weeks, no significant decrease was observed in the levels of the lipid parameters of normal rats treated with 1000 mg/kg of methanolic extract of leaf. In contrast, significant changes were observed in lipid parameters of high-fat diet induced hyperlipidemic rats after treated with 500 and 1000 mg/kg leaf methanolic extract as compared with the hyperlipidaemic control.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Sultan Ayesh, Mohammed Saghir
author_facet	Sultan Ayesh, Mohammed Saghir
author_sort	Sultan Ayesh, Mohammed Saghir
title	Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_short	Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_full	Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_fullStr	Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_full_unstemmed	Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_sort	antihyperlipidaemic and antioxidant activities of extracts of different parts of averrhoa carambola and elucidation of their mechanisms of action
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi (School of Pharmaceutical Sciences)
publishDate	2015
url	http://eprints.usm.my/32289/1/SULTAN_AYESH_MOHAMMED_SAGHIR_24%28NN%29.pdf
_version_	1747820559384707072

Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action

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