Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy

Hypertension is a major public health problem because of its consequences. Its treatment is crucial and goals include to decrease ~orbidity and mortality associated with hypertension by decreaSing blood pressure using drugs that have good tolerance, dosing convenience and low cost. As many antihyper...

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Main Author:	Ismail, Marina
Format:	Thesis
Language:	English
Published:	2001
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/37327/1/dr_marina_ismail%28MRM%29-RC31-1245_INT_MEDINICE.pdf
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id	my-usm-ep.37327
record_format	uketd_dc
spelling	my-usm-ep.373272019-04-12T05:27:05Z Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy 2001 Ismail, Marina RC31-1245 Internal medicine Hypertension is a major public health problem because of its consequences. Its treatment is crucial and goals include to decrease ~orbidity and mortality associated with hypertension by decreaSing blood pressure using drugs that have good tolerance, dosing convenience and low cost. As many antihypertensives are now available, it is important to choose the most appropriate drug in terms of efficacy and with least side effect in order to improve compliance and the patient's quality of life. In HUSM, metoprolol is a widely used. Its metabolism is mediated by the polymorphic debrisoquinehydroxylase that exhibits large inter ethnic difference. As most of its adverse reactions could be due to excessive plasma concentrations, its use among our local population may therefore be associated with adverse effects due to reduced capacity of the local population to metabolise the drug. The objedives of this study were therefore to investigate the use of metoprolol in the treatment of hypertension in relation to the incidence of adverse drug reactions it caused. We would also determine whether patients who experienced adverse reactions suffered reduced quality of life. As controls, we used patients who received enalapril or enalapril combined with metoprolol in the treatment of their hypertension. 2001 Thesis http://eprints.usm.my/37327/ http://eprints.usm.my/37327/1/dr_marina_ismail%28MRM%29-RC31-1245_INT_MEDINICE.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Ismail, Marina Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy
description	Hypertension is a major public health problem because of its consequences. Its treatment is crucial and goals include to decrease ~orbidity and mortality associated with hypertension by decreaSing blood pressure using drugs that have good tolerance, dosing convenience and low cost. As many antihypertensives are now available, it is important to choose the most appropriate drug in terms of efficacy and with least side effect in order to improve compliance and the patient's quality of life. In HUSM, metoprolol is a widely used. Its metabolism is mediated by the polymorphic debrisoquinehydroxylase that exhibits large inter ethnic difference. As most of its adverse reactions could be due to excessive plasma concentrations, its use among our local population may therefore be associated with adverse effects due to reduced capacity of the local population to metabolise the drug. The objedives of this study were therefore to investigate the use of metoprolol in the treatment of hypertension in relation to the incidence of adverse drug reactions it caused. We would also determine whether patients who experienced adverse reactions suffered reduced quality of life. As controls, we used patients who received enalapril or enalapril combined with metoprolol in the treatment of their hypertension.
format	Thesis
qualification_level	Master's degree
author	Ismail, Marina
author_facet	Ismail, Marina
author_sort	Ismail, Marina
title	Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy
title_short	Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy
title_full	Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy
title_fullStr	Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy
title_full_unstemmed	Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy
title_sort	studies on side effect profile of treated hypertensives on selected pharmacotherapy
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2001
url	http://eprints.usm.my/37327/1/dr_marina_ismail%28MRM%29-RC31-1245_INT_MEDINICE.pdf
_version_	1747820659248988160

Studies On Side Effect Profile Of Treated Hypertensives On Selected Pharmacotherapy

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