A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies

Objectives : This study is to compare between Cystatin C and 24 hour urine creatinine clearance for detection of renal impairment in hypertensive pregnancies population. Study Methods: 64 patients enrolled in this cross sectional study and each patient was required to collect 24 hour urine and 15 ml...

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Main Author:	Jummaat , Fauziah
Format:	Thesis
Language:	English
Published:	2011
Subjects:	RG551-591 Pregnancy
Online Access:	http://eprints.usm.my/37838/1/Pages_from_Fauziah_Jummaat-RG551_pregnancy.pdf
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id	my-usm-ep.37838
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spelling	my-usm-ep.378382019-04-12T05:26:36Z A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies 2011-05 Jummaat , Fauziah RG551-591 Pregnancy Objectives : This study is to compare between Cystatin C and 24 hour urine creatinine clearance for detection of renal impairment in hypertensive pregnancies population. Study Methods: 64 patients enrolled in this cross sectional study and each patient was required to collect 24 hour urine and 15 mls of blood. Blood taking was taken once in second and third trimester. Urine collection was carried out during the first visit. Creatinine clearance below 90 mls/min is taken as renal impairment and compared to the serum Cystatin C level. The Receiver Operating Characteristic Curve is drawn to obtain the sensitivity and specificity of Cystatin C. Results : The results have shown that when compared to 24 hour urine creatinine clearance, in second trimester, Cystatin C is 84.6 % sensitive and 86.7% specific for detection of renal impairment at Cystatin C level of 0.574-0.898 (p value < 0.012) , area under curve: 0.736, positive predictive value is 0.92 and negative predictive value is 0.76. While in the third trimester, the sensitivity and specificity is 76.9% and 60% at the Cystatin C level of 0.657-1.00 (p value < 0.006), area under curve 0.838, the positive predictive value is 0.71 and negative predictive value is 0.67. Conclusion: Our study suggests that Cystatin C is a useful diagnostic kit for diagnosis of renal impairment in hypertensive pregnancies population. 2011-05 Thesis http://eprints.usm.my/37838/ http://eprints.usm.my/37838/1/Pages_from_Fauziah_Jummaat-RG551_pregnancy.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG551-591 Pregnancy
spellingShingle	RG551-591 Pregnancy Jummaat , Fauziah A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies
description	Objectives : This study is to compare between Cystatin C and 24 hour urine creatinine clearance for detection of renal impairment in hypertensive pregnancies population. Study Methods: 64 patients enrolled in this cross sectional study and each patient was required to collect 24 hour urine and 15 mls of blood. Blood taking was taken once in second and third trimester. Urine collection was carried out during the first visit. Creatinine clearance below 90 mls/min is taken as renal impairment and compared to the serum Cystatin C level. The Receiver Operating Characteristic Curve is drawn to obtain the sensitivity and specificity of Cystatin C. Results : The results have shown that when compared to 24 hour urine creatinine clearance, in second trimester, Cystatin C is 84.6 % sensitive and 86.7% specific for detection of renal impairment at Cystatin C level of 0.574-0.898 (p value < 0.012) , area under curve: 0.736, positive predictive value is 0.92 and negative predictive value is 0.76. While in the third trimester, the sensitivity and specificity is 76.9% and 60% at the Cystatin C level of 0.657-1.00 (p value < 0.006), area under curve 0.838, the positive predictive value is 0.71 and negative predictive value is 0.67. Conclusion: Our study suggests that Cystatin C is a useful diagnostic kit for diagnosis of renal impairment in hypertensive pregnancies population.
format	Thesis
qualification_level	Master's degree
author	Jummaat , Fauziah
author_facet	Jummaat , Fauziah
author_sort	Jummaat , Fauziah
title	A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies
title_short	A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies
title_full	A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies
title_fullStr	A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies
title_full_unstemmed	A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies
title_sort	pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2011
url	http://eprints.usm.my/37838/1/Pages_from_Fauziah_Jummaat-RG551_pregnancy.pdf
_version_	1747820676832559104

A pilot study on sensitivity and specificity of cystatin c in detecting renal impairment in hypertensive pregnancies

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