A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy

Introduction Ocular surface changes are commonly seen in diabetes mellitus. It can be made worse by either contact or non-contact laser photocoagulation (LP) in proliferative diabetic retinopathy (PDR). Objective The aim of the study is to evaluate the effects of contact and non-contact LP ther...

Full description

Saved in:

Bibliographic Details
Main Author:	Wan Wei, Loo
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/39811/1/Dr_Loo_Wan_Wei-24_pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.39811
record_format	uketd_dc
spelling	my-usm-ep.398112019-04-12T05:25:57Z A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy 2015 Wan Wei, Loo RE Ophthalmology Introduction Ocular surface changes are commonly seen in diabetes mellitus. It can be made worse by either contact or non-contact laser photocoagulation (LP) in proliferative diabetic retinopathy (PDR). Objective The aim of the study is to evaluate the effects of contact and non-contact LP therapy on ocular surface changes and Ocular Surface Disease Index (OSDI) score in patients with PDR. Methods This is a randomized controlled trial in Hospital Universiti Sains Malaysia from June 2013 to May 2015. Patient with PDR was selected and randomized into 2 groups by using random sampling envelope method, Contact LP group and Non-contact LP group. Patients were evaluated for Schirmer test, tear film break-up time (TBUT) and assessment of OSDI questionnaire before treatment and 3 months post laser treatment. Statistical analyses were performed using SPSS version 22.0. Results A total of 60 eyes from 34 patients were recruited (Contact LP: 30 eyes from 17 patients and Non-contact LP: 30 eyes from 17 patients). There was no significant difference in mean change of the Schirmer test (p=0.378) at 3 months post treatment between the two groups. Although there was significant reduction in TBUT at 3 months post laser in Contact LP group (p=0.038), but there was no significant difference in mean change of TBUT between the two groups (p=0.549). There was significant increased in mean change of OSDI score at 3 months post treatment in Contact LP group as compared to Non-contact LP group (p=0.044). Conclusion Contact LP resulted in significant worsening of TBUT and increasing in OSDI sore. However, non-contact LP may not minimize the effect of laser on ocular surface of diabetic retinopathy patients. Appropriate care should be given to the ocular surface of diabetic retinopathy patients during LP procedure. 2015 Thesis http://eprints.usm.my/39811/ http://eprints.usm.my/39811/1/Dr_Loo_Wan_Wei-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Wan Wei, Loo A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy
description	Introduction Ocular surface changes are commonly seen in diabetes mellitus. It can be made worse by either contact or non-contact laser photocoagulation (LP) in proliferative diabetic retinopathy (PDR). Objective The aim of the study is to evaluate the effects of contact and non-contact LP therapy on ocular surface changes and Ocular Surface Disease Index (OSDI) score in patients with PDR. Methods This is a randomized controlled trial in Hospital Universiti Sains Malaysia from June 2013 to May 2015. Patient with PDR was selected and randomized into 2 groups by using random sampling envelope method, Contact LP group and Non-contact LP group. Patients were evaluated for Schirmer test, tear film break-up time (TBUT) and assessment of OSDI questionnaire before treatment and 3 months post laser treatment. Statistical analyses were performed using SPSS version 22.0. Results A total of 60 eyes from 34 patients were recruited (Contact LP: 30 eyes from 17 patients and Non-contact LP: 30 eyes from 17 patients). There was no significant difference in mean change of the Schirmer test (p=0.378) at 3 months post treatment between the two groups. Although there was significant reduction in TBUT at 3 months post laser in Contact LP group (p=0.038), but there was no significant difference in mean change of TBUT between the two groups (p=0.549). There was significant increased in mean change of OSDI score at 3 months post treatment in Contact LP group as compared to Non-contact LP group (p=0.044). Conclusion Contact LP resulted in significant worsening of TBUT and increasing in OSDI sore. However, non-contact LP may not minimize the effect of laser on ocular surface of diabetic retinopathy patients. Appropriate care should be given to the ocular surface of diabetic retinopathy patients during LP procedure.
format	Thesis
qualification_level	Master's degree
author	Wan Wei, Loo
author_facet	Wan Wei, Loo
author_sort	Wan Wei, Loo
title	A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy
title_short	A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy
title_full	A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy
title_fullStr	A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy
title_full_unstemmed	A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy
title_sort	randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2015
url	http://eprints.usm.my/39811/1/Dr_Loo_Wan_Wei-24_pages.pdf
_version_	1747820770654945280

A randomised controlled trial on effects of contact and non-contact laser photocoagulation therapy on ocular surface in patients with proliferative diabetic retinopathy

Similar Items