Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia

Introduction: Autologous peripheral blood stem cells transplantation (APBSCT) is a therapeutic option which can be used in various haematological neoplastic disorders. In Hospital Universiti Sains Malaysia (HUSM), APBSCT is practiced in multiple myeloma and lymphoma cases as it is associated with su...

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Main Author:	Mohamed Fauzi, Hafizuddin
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RC Internal medicine
Online Access:	http://eprints.usm.my/40195/1/Dr._Hafizuddin_Mohamed_Fauzi_%28Haematology%29-24_pages.pdf
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spelling	my-usm-ep.401952019-04-12T05:25:55Z Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia 2015 Mohamed Fauzi, Hafizuddin RC Internal medicine Introduction: Autologous peripheral blood stem cells transplantation (APBSCT) is a therapeutic option which can be used in various haematological neoplastic disorders. In Hospital Universiti Sains Malaysia (HUSM), APBSCT is practiced in multiple myeloma and lymphoma cases as it is associated with substantial advantages and fewer complications compared to allogenic stem cell transplantation. Objectives: The aim of this study was to identify factors associated with rapid haematopoietic engraftment in lymphoproliferative disease patients undergoing APBSCT. Methodology: A retrospective data analysis was done on lymphoma and multiple myeloma patients treated with APBSCT at HUSM from 2010 until 2013.Data was collected from the record file Haematology Patient Information System (HPIS) in the institution intranet. Twelve factors were analyzed to determine the engraftment time for platelet and neutrophil. Engraftment of neutrophils is defined as count at least 0.5 x 109/L for three consecutive days and platelet count at least 20 x 109/L for seven consecutive days without transfusion support. Early engraftment for both neutrophils and platelet were defined as less than 14 days from the day of stem cell infusion. Data were analyzed using Pearson Chi Square/ Fisher’s Exact and significant factors were analysed with Multiple Logistic Regression test with p < 0.05 indicates statistically significance. Results: Forty patients had been studied, the results showed that 95% patients had successful neutrophil engraftment and 82.5% patients had successful platelet engraftment. From these success groups, the main predictive factor for rapid engraftment for neutrophil is stem cell (CD34+) count while predictive factors that influenced rapid platelet engraftment were (CD34+) count and the stage of the disease at diagnosis. Conclusion: In conclusion, identifying factors that may benefit patients undergoing stem cell transplantation are important and the results obtained can be useful as a guidance to clinical haematologists to optimize their management. 2015 Thesis http://eprints.usm.my/40195/ http://eprints.usm.my/40195/1/Dr._Hafizuddin_Mohamed_Fauzi_%28Haematology%29-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Mohamed Fauzi, Hafizuddin Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia
description	Introduction: Autologous peripheral blood stem cells transplantation (APBSCT) is a therapeutic option which can be used in various haematological neoplastic disorders. In Hospital Universiti Sains Malaysia (HUSM), APBSCT is practiced in multiple myeloma and lymphoma cases as it is associated with substantial advantages and fewer complications compared to allogenic stem cell transplantation. Objectives: The aim of this study was to identify factors associated with rapid haematopoietic engraftment in lymphoproliferative disease patients undergoing APBSCT. Methodology: A retrospective data analysis was done on lymphoma and multiple myeloma patients treated with APBSCT at HUSM from 2010 until 2013.Data was collected from the record file Haematology Patient Information System (HPIS) in the institution intranet. Twelve factors were analyzed to determine the engraftment time for platelet and neutrophil. Engraftment of neutrophils is defined as count at least 0.5 x 109/L for three consecutive days and platelet count at least 20 x 109/L for seven consecutive days without transfusion support. Early engraftment for both neutrophils and platelet were defined as less than 14 days from the day of stem cell infusion. Data were analyzed using Pearson Chi Square/ Fisher’s Exact and significant factors were analysed with Multiple Logistic Regression test with p < 0.05 indicates statistically significance. Results: Forty patients had been studied, the results showed that 95% patients had successful neutrophil engraftment and 82.5% patients had successful platelet engraftment. From these success groups, the main predictive factor for rapid engraftment for neutrophil is stem cell (CD34+) count while predictive factors that influenced rapid platelet engraftment were (CD34+) count and the stage of the disease at diagnosis. Conclusion: In conclusion, identifying factors that may benefit patients undergoing stem cell transplantation are important and the results obtained can be useful as a guidance to clinical haematologists to optimize their management.
format	Thesis
qualification_level	Master's degree
author	Mohamed Fauzi, Hafizuddin
author_facet	Mohamed Fauzi, Hafizuddin
author_sort	Mohamed Fauzi, Hafizuddin
title	Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia
title_short	Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia
title_full	Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia
title_fullStr	Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia
title_full_unstemmed	Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia
title_sort	factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2015
url	http://eprints.usm.my/40195/1/Dr._Hafizuddin_Mohamed_Fauzi_%28Haematology%29-24_pages.pdf
_version_	1747820788327645184

Factors influencing engraftment in peripheral autologous haematopoietic stem cell transplantation for lymphoproliferative disease patients in Hospital Universiti Sains Malaysia

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