Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia

Background: HyperPRL is the most common hypothalamic-pituitary disorder encountered in clinical endocrinology. Macroprolactinemia is a known benign cause of hyperPRL. Macroprolactin is a non-bioactive form of PRL, composed of monomeric PRL and Immunoglobulin G antibodies. The prevalence of macrop...

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Main Author:	Che Soh @ Yusof, Noor Azlin Azraini
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RC648-665 Diseases of the endocrine glands Clinical endocrinology
Online Access:	http://eprints.usm.my/40634/1/Dr._Noor_Azlin_Azraini_Che_Soh%40Yusof-24_pages.pdf
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spelling	my-usm-ep.406342018-07-16T01:18:19Z Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia 2015 Che Soh @ Yusof, Noor Azlin Azraini RC648-665 Diseases of the endocrine glands. Clinical endocrinology Background: HyperPRL is the most common hypothalamic-pituitary disorder encountered in clinical endocrinology. Macroprolactinemia is a known benign cause of hyperPRL. Macroprolactin is a non-bioactive form of PRL, composed of monomeric PRL and Immunoglobulin G antibodies. The prevalence of macroprolactinemia is increasing in endocrinology practice. It is important to differentiate between macroprolactinemia and hyperPRL as macroprolactinemia does not require any treatment. However the clinical symptoms are could not differentiate between these two conditions. Aim: To determine the prevalence of macroprolactinemia and significant clinical features associated with macroprolactinemia among hyperPRL patient in HUSM. Design: A cross sectional study was conducted in 2013 involving patients diagnosed as hyperPRL in HUSM from 2011 to 2013. Serum from these patient were measured for PRL using cobas e411 (sandwich principle) and the same serum were treated with polyethylene glycol (PEG) 8000 to differentiate true hyperPRL and macroprolactinemia. PRL recovery of less than 40% indicates of presence macroprolactin. Results: A total of 133 hyperPRL patients, 120 (90%) female and 13 (9.8%) male aged between 18 to 68 years old with mean (SD) age of 34.37 (11.75) years old were included in this study. Nine patients (all female) were found to have macroprolactinemia [prevalence=6.8% (95% CI: 2.4%, 11.1%)]. There were no significant association between clinical symptoms and diagnosis of macroprolactinemia in this study. Conclusion: The prevalence of macroprolactinemia detected using PEG 8000 among patients diagnosed as hyperPRL was low. Screening for macroprolactin using PEG 8000 showed that majority of patients presented with hyperPRL in HUSM were true hyperPRL. Clinical symptoms alone therefore, could not distinguish between hyperPRL and macroprolactinemia. 2015 Thesis http://eprints.usm.my/40634/ http://eprints.usm.my/40634/1/Dr._Noor_Azlin_Azraini_Che_Soh%40Yusof-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC648-665 Diseases of the endocrine glands Clinical endocrinology
spellingShingle	RC648-665 Diseases of the endocrine glands Clinical endocrinology Che Soh @ Yusof, Noor Azlin Azraini Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia
description	Background: HyperPRL is the most common hypothalamic-pituitary disorder encountered in clinical endocrinology. Macroprolactinemia is a known benign cause of hyperPRL. Macroprolactin is a non-bioactive form of PRL, composed of monomeric PRL and Immunoglobulin G antibodies. The prevalence of macroprolactinemia is increasing in endocrinology practice. It is important to differentiate between macroprolactinemia and hyperPRL as macroprolactinemia does not require any treatment. However the clinical symptoms are could not differentiate between these two conditions. Aim: To determine the prevalence of macroprolactinemia and significant clinical features associated with macroprolactinemia among hyperPRL patient in HUSM. Design: A cross sectional study was conducted in 2013 involving patients diagnosed as hyperPRL in HUSM from 2011 to 2013. Serum from these patient were measured for PRL using cobas e411 (sandwich principle) and the same serum were treated with polyethylene glycol (PEG) 8000 to differentiate true hyperPRL and macroprolactinemia. PRL recovery of less than 40% indicates of presence macroprolactin. Results: A total of 133 hyperPRL patients, 120 (90%) female and 13 (9.8%) male aged between 18 to 68 years old with mean (SD) age of 34.37 (11.75) years old were included in this study. Nine patients (all female) were found to have macroprolactinemia [prevalence=6.8% (95% CI: 2.4%, 11.1%)]. There were no significant association between clinical symptoms and diagnosis of macroprolactinemia in this study. Conclusion: The prevalence of macroprolactinemia detected using PEG 8000 among patients diagnosed as hyperPRL was low. Screening for macroprolactin using PEG 8000 showed that majority of patients presented with hyperPRL in HUSM were true hyperPRL. Clinical symptoms alone therefore, could not distinguish between hyperPRL and macroprolactinemia.
format	Thesis
qualification_level	Master's degree
author	Che Soh @ Yusof, Noor Azlin Azraini
author_facet	Che Soh @ Yusof, Noor Azlin Azraini
author_sort	Che Soh @ Yusof, Noor Azlin Azraini
title	Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia
title_short	Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia
title_full	Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia
title_fullStr	Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia
title_full_unstemmed	Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia
title_sort	macroprolactinemia among hyperprolactinemia patients in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2015
url	http://eprints.usm.my/40634/1/Dr._Noor_Azlin_Azraini_Che_Soh%40Yusof-24_pages.pdf
_version_	1747820798589009920

Macroprolactinemia among hyperprolactinemia patients in Hospital Universiti Sains Malaysia

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