Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System

Poly(lactic acid) (PLA) microspheres were fabricated through emulsion and solvent evaporation (ESE) technique. The particle size distributions (PSD) of microspheres obtained were in the range of 1- 250 μm, as within the range of acceptable size in parenteral injection. A shake flask method was demon...

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Main Author:	Tham , Cho Yin
Format:	Thesis
Language:	English
Published:	2015
Subjects:	TN263-271 Mineral deposits Metallic ore deposits Prospecting
Online Access:	http://eprints.usm.my/40947/1/THAM_CHO_YIN_24_pages.pdf
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spelling	my-usm-ep.409472018-07-09T02:25:42Z Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System 2015 Tham , Cho Yin TN263-271 Mineral deposits. Metallic ore deposits. Prospecting Poly(lactic acid) (PLA) microspheres were fabricated through emulsion and solvent evaporation (ESE) technique. The particle size distributions (PSD) of microspheres obtained were in the range of 1- 250 μm, as within the range of acceptable size in parenteral injection. A shake flask method was demonstrated as an alternative technique to determine the encapsulation feasibility of an ESE system. Herein, dichloromethane-water solvent pair was used in shake flask system in order to simulate ESE system, and Rhodamine B was utilized as model drug throughout the project. In the fabrication of microspheres, the studies parameters were included PLA concentration, PVA concentration and dispersed phase volume ratio (DP). The effect of parameters on PSD range, surface morphology and encapsulation efficiency were evaluated. The optimum formulation was at 25 % DP, 15 % PLA and 1 % PVA, wherein the highest output of microspheres obtained at lowest PVA consumption in the system and narrow PSD obtained in range 1- 50 μm. In this formulation, extensive foaming of emulsion was observed during the emulsification process. It was suggested that the dispersed droplets tends to stay within the foam structure which further provide extra stabilization between droplets or partial solidified particles. The surfaces of microspheres were modified through catalytic induced hydrolysis technique. The surface and bulk properties of treated microspheres were investigated to verify the effectiveness of hydrolysis technique. Results demonstrated that the factors included timescale, type of catalyst and concentration should be manipulated in order to obtain the desired surface properties (e.g. hydrophilicity, surface charges and surface morphology) with minium deformation in microspheres bulk properti 2015 Thesis http://eprints.usm.my/40947/ http://eprints.usm.my/40947/1/THAM_CHO_YIN_24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	TN263-271 Mineral deposits Metallic ore deposits Prospecting
spellingShingle	TN263-271 Mineral deposits Metallic ore deposits Prospecting Tham , Cho Yin Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System
description	Poly(lactic acid) (PLA) microspheres were fabricated through emulsion and solvent evaporation (ESE) technique. The particle size distributions (PSD) of microspheres obtained were in the range of 1- 250 μm, as within the range of acceptable size in parenteral injection. A shake flask method was demonstrated as an alternative technique to determine the encapsulation feasibility of an ESE system. Herein, dichloromethane-water solvent pair was used in shake flask system in order to simulate ESE system, and Rhodamine B was utilized as model drug throughout the project. In the fabrication of microspheres, the studies parameters were included PLA concentration, PVA concentration and dispersed phase volume ratio (DP). The effect of parameters on PSD range, surface morphology and encapsulation efficiency were evaluated. The optimum formulation was at 25 % DP, 15 % PLA and 1 % PVA, wherein the highest output of microspheres obtained at lowest PVA consumption in the system and narrow PSD obtained in range 1- 50 μm. In this formulation, extensive foaming of emulsion was observed during the emulsification process. It was suggested that the dispersed droplets tends to stay within the foam structure which further provide extra stabilization between droplets or partial solidified particles. The surfaces of microspheres were modified through catalytic induced hydrolysis technique. The surface and bulk properties of treated microspheres were investigated to verify the effectiveness of hydrolysis technique. Results demonstrated that the factors included timescale, type of catalyst and concentration should be manipulated in order to obtain the desired surface properties (e.g. hydrophilicity, surface charges and surface morphology) with minium deformation in microspheres bulk properti
format	Thesis
qualification_level	Master's degree
author	Tham , Cho Yin
author_facet	Tham , Cho Yin
author_sort	Tham , Cho Yin
title	Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System
title_short	Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System
title_full	Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System
title_fullStr	Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System
title_full_unstemmed	Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System
title_sort	preparation of poly(lactic acid) (pla) microspheres for drug delivery system
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral
publishDate	2015
url	http://eprints.usm.my/40947/1/THAM_CHO_YIN_24_pages.pdf
_version_	1747820845883981824

Preparation Of Poly(Lactic Acid) (Pla) Microspheres For Drug Delivery System

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