Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells

Cytokines, like IL-6, play an important role in triggering the acute phase response (APR) of the body to injury and inflammation. The dynamics of expression and interaction of the IL-6 signalling pathway components in the regulation of peroxisome proliferator-activated receptor alpha (PPARα) during...

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Main Author:	Chew , Guat Siew
Format:	Thesis
Language:	English
Published:	2010
Subjects:	QH1 Natural history (General - Including nature conservation geographical distribution)
Online Access:	http://eprints.usm.my/41719/1/CHEW_GUAT_SIEW.pdf
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id	my-usm-ep.41719
record_format	uketd_dc
spelling	my-usm-ep.417192019-04-12T05:26:49Z Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells 2010-09 Chew , Guat Siew QH1 Natural history (General - Including nature conservation, geographical distribution) Cytokines, like IL-6, play an important role in triggering the acute phase response (APR) of the body to injury and inflammation. The dynamics of expression and interaction of the IL-6 signalling pathway components in the regulation of peroxisome proliferator-activated receptor alpha (PPARα) during APR remain to be properly identified. In this study, we determined that three possible potential signaling pathways, JAK-STAT, PI3K and MAPK (p38 and ERK1/2) which derived from the upstream JAK and SHP2 components of the IL-6 signalling were involved in IL-6-inhibitory effect on PPARα gene expression. 2010-09 Thesis http://eprints.usm.my/41719/ http://eprints.usm.my/41719/1/CHEW_GUAT_SIEW.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1 Natural history (General - Including nature conservation geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation geographical distribution) Chew , Guat Siew Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells
description	Cytokines, like IL-6, play an important role in triggering the acute phase response (APR) of the body to injury and inflammation. The dynamics of expression and interaction of the IL-6 signalling pathway components in the regulation of peroxisome proliferator-activated receptor alpha (PPARα) during APR remain to be properly identified. In this study, we determined that three possible potential signaling pathways, JAK-STAT, PI3K and MAPK (p38 and ERK1/2) which derived from the upstream JAK and SHP2 components of the IL-6 signalling were involved in IL-6-inhibitory effect on PPARα gene expression.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Chew , Guat Siew
author_facet	Chew , Guat Siew
author_sort	Chew , Guat Siew
title	Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells
title_short	Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells
title_full	Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells
title_fullStr	Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells
title_full_unstemmed	Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells
title_sort	molecular mechanism of acute phase response : identification of signal transduction pathways mediating cytokine inhibitory effect on human peroxisome proliferator activated receptor alpha (ppara) in liver cells
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2010
url	http://eprints.usm.my/41719/1/CHEW_GUAT_SIEW.pdf
_version_	1747820960774356992

Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells

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