Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine
There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS...
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2010
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my-usm-ep.417282019-04-12T05:26:58Z Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine 2010-01 Chitneni , Mallikarjun RS1-441 Pharmacy and materia medica There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS class IV drugs, namely sulpiride and norfloxacin. Sulpiride is a P-gp substrate and norfloxacin is a substrate of MRP2, BCRP and an unknown efflux pump. 2010-01 Thesis http://eprints.usm.my/41728/ http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi |
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Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Chitneni , Mallikarjun Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| description |
There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS class IV drugs, namely sulpiride and norfloxacin. Sulpiride is a P-gp substrate and norfloxacin is a
substrate of MRP2, BCRP and an unknown efflux pump. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Chitneni , Mallikarjun |
| author_facet |
Chitneni , Mallikarjun |
| author_sort |
Chitneni , Mallikarjun |
| title |
Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_short |
Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_full |
Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_fullStr |
Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_full_unstemmed |
Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_sort |
oral bioavailability enhancement of poorly soluble and poorly permeable drugs using self-microemulsifying drug delivery systems and the effect of piperine |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Farmasi |
| publishDate |
2010 |
| url |
http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf |
| _version_ |
1747820962725756928 |