Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma
Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tum...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2009
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| Subjects: | |
| Online Access: | http://eprints.usm.my/41836/1/HANANI_BINTI_AHMAD_YUSOF%40HANAFI.pdf |
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| Summary: | Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births.
Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tumor suppressor gene RB1 to be knockedout. Recent studies found mutation occurred more frequently in the pocket A and B domain of RB1 gene. The present study was undertaken to identify the mutation in the pocket A and B domain of RB1 gene among retinoblastoma patients in Malaysia, and the association of the mutation to the laterality and stage of the tumor. |
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