Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma
Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tum...
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2009
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my-usm-ep.418362019-04-12T05:26:59Z Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma 2009-12 Hanafi, Hanani Ahmad Yusof R5-920 Medicine (General) Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tumor suppressor gene RB1 to be knockedout. Recent studies found mutation occurred more frequently in the pocket A and B domain of RB1 gene. The present study was undertaken to identify the mutation in the pocket A and B domain of RB1 gene among retinoblastoma patients in Malaysia, and the association of the mutation to the laterality and stage of the tumor. 2009-12 Thesis http://eprints.usm.my/41836/ http://eprints.usm.my/41836/1/HANANI_BINTI_AHMAD_YUSOF%40HANAFI.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan |
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Universiti Sains Malaysia |
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USM Institutional Repository |
| language |
English |
| topic |
R5-920 Medicine (General) |
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R5-920 Medicine (General) Hanafi, Hanani Ahmad Yusof Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma |
| description |
Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births.
Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tumor suppressor gene RB1 to be knockedout. Recent studies found mutation occurred more frequently in the pocket A and B domain of RB1 gene. The present study was undertaken to identify the mutation in the pocket A and B domain of RB1 gene among retinoblastoma patients in Malaysia, and the association of the mutation to the laterality and stage of the tumor. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Hanafi, Hanani Ahmad Yusof |
| author_facet |
Hanafi, Hanani Ahmad Yusof |
| author_sort |
Hanafi, Hanani Ahmad Yusof |
| title |
Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_short |
Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_full |
Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_fullStr |
Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_full_unstemmed |
Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_sort |
genetic study of pocket a and b domain of rb1 gene among
malaysian children with retinoblastoma |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Perubatan |
| publishDate |
2009 |
| url |
http://eprints.usm.my/41836/1/HANANI_BINTI_AHMAD_YUSOF%40HANAFI.pdf |
| _version_ |
1747820980248510464 |