Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan

The rate limiting step of bilirubin excretion is the glucuronidation of bilirubin in the liver, a process that is catalyzed by an enzyme, Uridine glucuronyl transferase. This enzyme is encoded by the UGT1A1 gene. In several populations, mutations in this gene have been shown to cause neonatal jaundi...

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Main Author:	Ma'amor, Nur Hasnah
Format:	Thesis
Language:	English
Published:	2012
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/42246/1/NUR_HASNAH_MA%27AMOR.pdf
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id	my-usm-ep.42246
record_format	uketd_dc
spelling	my-usm-ep.422462019-04-12T05:26:22Z Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan 2012-04 Ma'amor, Nur Hasnah R5-920 Medicine (General) The rate limiting step of bilirubin excretion is the glucuronidation of bilirubin in the liver, a process that is catalyzed by an enzyme, Uridine glucuronyl transferase. This enzyme is encoded by the UGT1A1 gene. In several populations, mutations in this gene have been shown to cause neonatal jaundice. However data on the Malaysian Malay population are scanty at best. The objectives of this study included: to determine the frequency of variants in the exons of the UGT1A1 gene in a population of term Malay neonates with jaundice and without jaundice, and to correlate the genotype finding with some phenotypic data. 2012-04 Thesis http://eprints.usm.my/42246/ http://eprints.usm.my/42246/1/NUR_HASNAH_MA%27AMOR.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Ma'amor, Nur Hasnah Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan
description	The rate limiting step of bilirubin excretion is the glucuronidation of bilirubin in the liver, a process that is catalyzed by an enzyme, Uridine glucuronyl transferase. This enzyme is encoded by the UGT1A1 gene. In several populations, mutations in this gene have been shown to cause neonatal jaundice. However data on the Malaysian Malay population are scanty at best. The objectives of this study included: to determine the frequency of variants in the exons of the UGT1A1 gene in a population of term Malay neonates with jaundice and without jaundice, and to correlate the genotype finding with some phenotypic data.
format	Thesis
qualification_level	Master's degree
author	Ma'amor, Nur Hasnah
author_facet	Ma'amor, Nur Hasnah
author_sort	Ma'amor, Nur Hasnah
title	Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan
title_short	Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan
title_full	Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan
title_fullStr	Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan
title_full_unstemmed	Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan
title_sort	screening of ugt1a1 gene and genotype-phenotype correlationship in neonatal jaundice from a sample of newborns in kelantan
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2012
url	http://eprints.usm.my/42246/1/NUR_HASNAH_MA%27AMOR.pdf
_version_	1747821043320356864

Screening Of UGT1A1 Gene And Genotype-Phenotype Correlationship In Neonatal Jaundice From A Sample Of Newborns In Kelantan

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