Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia

Background: Post-anaesthesia shivering is physiologically and psychologically stressful event. Pethidine, which is commonly recognised as first-line therapy, can have several side effects such as sedative effects, nausea and vomiting. Granisetron has been proven in various studies for prevention...

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Main Author:	Teoh, Jui Chang
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RD Surgery
Online Access:	http://eprints.usm.my/42520/1/Dr._Teoh_Jui_Chang-24_pages.pdf
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spelling	my-usm-ep.425202019-04-12T05:25:33Z Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia 2016 Teoh, Jui Chang RD Surgery Background: Post-anaesthesia shivering is physiologically and psychologically stressful event. Pethidine, which is commonly recognised as first-line therapy, can have several side effects such as sedative effects, nausea and vomiting. Granisetron has been proven in various studies for prevention of post-anaesthesia shivering at 40mcg/kg intravenously. To date, no study has demonstrated the minimum dose of granisetron to prevent post-anaesthesia shivering. This study compared two different dosages of intravenous granisetron versus pethidine for prevention of post-anaesthesia shivering. Methods: This was a prospective, randomized, double-blinded study. A total of 96 patients with ASA classification I and II, aged between 18 and 65 years old scheduled for orthopaedic lower limb surgery under spinal anaesthesia were recruited. Patients were randomly allocated to receive either intravenous (IV) granisetron 10mcg/kg (Group 1), IV granisetron 40mcg/kg (Group 2) or IV pethidine 0.4mg/kg (Group 3) before an intrathecal injection of 15 mg 0.5% hyperbaric bupivacaine. The incidence and severity of shivering with side effects of tested drugs were recorded. Results: The incidence of shivering associated with spinal anaesthesia in our study was not significant different amongst the 3 groups (p = 0.404). However, pethidine was associated with sedative effects when compared with granisetron (p < 0.001). Conclusions: IV granisetron at 10mcg/kg had similar efficacy when compared to both IV granisetron 40mcg/kg and IV pethidine 0.4mg/kg in preventing shivering during spinal anaesthesia for orthopaedic lower limb surgery. 2016 Thesis http://eprints.usm.my/42520/ http://eprints.usm.my/42520/1/Dr._Teoh_Jui_Chang-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RD Surgery
spellingShingle	RD Surgery Teoh, Jui Chang Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
description	Background: Post-anaesthesia shivering is physiologically and psychologically stressful event. Pethidine, which is commonly recognised as first-line therapy, can have several side effects such as sedative effects, nausea and vomiting. Granisetron has been proven in various studies for prevention of post-anaesthesia shivering at 40mcg/kg intravenously. To date, no study has demonstrated the minimum dose of granisetron to prevent post-anaesthesia shivering. This study compared two different dosages of intravenous granisetron versus pethidine for prevention of post-anaesthesia shivering. Methods: This was a prospective, randomized, double-blinded study. A total of 96 patients with ASA classification I and II, aged between 18 and 65 years old scheduled for orthopaedic lower limb surgery under spinal anaesthesia were recruited. Patients were randomly allocated to receive either intravenous (IV) granisetron 10mcg/kg (Group 1), IV granisetron 40mcg/kg (Group 2) or IV pethidine 0.4mg/kg (Group 3) before an intrathecal injection of 15 mg 0.5% hyperbaric bupivacaine. The incidence and severity of shivering with side effects of tested drugs were recorded. Results: The incidence of shivering associated with spinal anaesthesia in our study was not significant different amongst the 3 groups (p = 0.404). However, pethidine was associated with sedative effects when compared with granisetron (p < 0.001). Conclusions: IV granisetron at 10mcg/kg had similar efficacy when compared to both IV granisetron 40mcg/kg and IV pethidine 0.4mg/kg in preventing shivering during spinal anaesthesia for orthopaedic lower limb surgery.
format	Thesis
qualification_level	Master's degree
author	Teoh, Jui Chang
author_facet	Teoh, Jui Chang
author_sort	Teoh, Jui Chang
title	Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_short	Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_full	Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_fullStr	Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_full_unstemmed	Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_sort	comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42520/1/Dr._Teoh_Jui_Chang-24_pages.pdf
_version_	1747821079010738176

Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia

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