Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
Introduction: The main issue in osteoarthritis is the risk of pain and physical disability. Knee osteoarthritis is one of the commonest joint disorders that lead to physical disability. Elderly women experience lower quality of life due to functional limitation and physical disability than male....
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| Format: | Thesis |
| Language: | English |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://eprints.usm.my/42541/1/Dr._Nurul_Fakhri_Amir-24_pages.pdf |
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| Summary: | Introduction: The main issue in osteoarthritis is the risk of pain and physical disability.
Knee osteoarthritis is one of the commonest joint disorders that lead to physical
disability. Elderly women experience lower quality of life due to functional limitation
and physical disability than male. Main factor that cause physical disability are
increasing age, obesity, lack of exercise, previous knee injury and medical comorbidity.
In human, finger length ratio (2D:4D) is a sexually dimorphic trait. Generally,
males have low 2D:4D ratio; a ring finger that is longer than their index finger. While
female typically have high or equal 2D: 4D ratio, index finger longer than ring fingers
or the same length. Different digit ratio associated with human physical capability,
attitude and characteristic. Previous study suggested that low 2D:4D ratio associated
with higher risk to developed knee osteoarthritis in women.
Objectives: To determine association between WOMAC score, Body Mass Index
(BMI) with 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis.
Patients and Methods: We conducted cross sectional study in 118 women with knee
osteoarthritis (Kellgren Lawrence grade 2 -3), who completed the Western Ontario and
McMaster Osteoarthritis Index (WOMAC) questionnaire. Length of index finger and
ring finger were measured from right hand radiographs. Subjects were classified into
three groups: type I (index finger longer than ring finger), type II (equal length) and
type III (index finger shorter than ring finger). Body Mass Index (BMI) was measured
and recorded by standard procedure.Result: The majority of the participants were classified under type III finger pattern
n=56 (47%). However, this study showed there was no significant mean difference
between mean total WOMAC score and each component with 2D:4D ratio. BMI
correlated significantly with worse knee OA symptoms for total WOMAC score (pvalue<
0.001, r = 0.643). There was a significant association between 2D:4D ratio and
Body Mass Index (BMI) (F-stat (df) 4.38 (2), P-value 0.015) and higher BMI majority
in type II (mean (SD) 30.2 (4.31)).
Conclusion: There is no association between WOMAC score and 2D:4D ratio in
women with grade 2 and 3 of knee osteoarthritis. It means that different type of finger
pattern does not affect the severity of physical disability. However, the study showed
positive correlation between total WOMAC score and higher Body Mass Index (BMI)
and significant association between 2D:4D ratio and higher Body Mass Index (BMI).
Those with higher Body Mass Index (BMI) majority in type II |
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