Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis

Introduction: The main issue in osteoarthritis is the risk of pain and physical disability. Knee osteoarthritis is one of the commonest joint disorders that lead to physical disability. Elderly women experience lower quality of life due to functional limitation and physical disability than male....

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Main Author:	Amir, Nurul Fakhri
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RC Internal medicine
Online Access:	http://eprints.usm.my/42541/1/Dr._Nurul_Fakhri_Amir-24_pages.pdf
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spelling	my-usm-ep.425412019-04-12T05:25:28Z Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis 2016 Amir, Nurul Fakhri RC Internal medicine Introduction: The main issue in osteoarthritis is the risk of pain and physical disability. Knee osteoarthritis is one of the commonest joint disorders that lead to physical disability. Elderly women experience lower quality of life due to functional limitation and physical disability than male. Main factor that cause physical disability are increasing age, obesity, lack of exercise, previous knee injury and medical comorbidity. In human, finger length ratio (2D:4D) is a sexually dimorphic trait. Generally, males have low 2D:4D ratio; a ring finger that is longer than their index finger. While female typically have high or equal 2D: 4D ratio, index finger longer than ring fingers or the same length. Different digit ratio associated with human physical capability, attitude and characteristic. Previous study suggested that low 2D:4D ratio associated with higher risk to developed knee osteoarthritis in women. Objectives: To determine association between WOMAC score, Body Mass Index (BMI) with 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. Patients and Methods: We conducted cross sectional study in 118 women with knee osteoarthritis (Kellgren Lawrence grade 2 -3), who completed the Western Ontario and McMaster Osteoarthritis Index (WOMAC) questionnaire. Length of index finger and ring finger were measured from right hand radiographs. Subjects were classified into three groups: type I (index finger longer than ring finger), type II (equal length) and type III (index finger shorter than ring finger). Body Mass Index (BMI) was measured and recorded by standard procedure.Result: The majority of the participants were classified under type III finger pattern n=56 (47%). However, this study showed there was no significant mean difference between mean total WOMAC score and each component with 2D:4D ratio. BMI correlated significantly with worse knee OA symptoms for total WOMAC score (pvalue< 0.001, r = 0.643). There was a significant association between 2D:4D ratio and Body Mass Index (BMI) (F-stat (df) 4.38 (2), P-value 0.015) and higher BMI majority in type II (mean (SD) 30.2 (4.31)). Conclusion: There is no association between WOMAC score and 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. It means that different type of finger pattern does not affect the severity of physical disability. However, the study showed positive correlation between total WOMAC score and higher Body Mass Index (BMI) and significant association between 2D:4D ratio and higher Body Mass Index (BMI). Those with higher Body Mass Index (BMI) majority in type II 2016 Thesis http://eprints.usm.my/42541/ http://eprints.usm.my/42541/1/Dr._Nurul_Fakhri_Amir-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Amir, Nurul Fakhri Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
description	Introduction: The main issue in osteoarthritis is the risk of pain and physical disability. Knee osteoarthritis is one of the commonest joint disorders that lead to physical disability. Elderly women experience lower quality of life due to functional limitation and physical disability than male. Main factor that cause physical disability are increasing age, obesity, lack of exercise, previous knee injury and medical comorbidity. In human, finger length ratio (2D:4D) is a sexually dimorphic trait. Generally, males have low 2D:4D ratio; a ring finger that is longer than their index finger. While female typically have high or equal 2D: 4D ratio, index finger longer than ring fingers or the same length. Different digit ratio associated with human physical capability, attitude and characteristic. Previous study suggested that low 2D:4D ratio associated with higher risk to developed knee osteoarthritis in women. Objectives: To determine association between WOMAC score, Body Mass Index (BMI) with 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. Patients and Methods: We conducted cross sectional study in 118 women with knee osteoarthritis (Kellgren Lawrence grade 2 -3), who completed the Western Ontario and McMaster Osteoarthritis Index (WOMAC) questionnaire. Length of index finger and ring finger were measured from right hand radiographs. Subjects were classified into three groups: type I (index finger longer than ring finger), type II (equal length) and type III (index finger shorter than ring finger). Body Mass Index (BMI) was measured and recorded by standard procedure.Result: The majority of the participants were classified under type III finger pattern n=56 (47%). However, this study showed there was no significant mean difference between mean total WOMAC score and each component with 2D:4D ratio. BMI correlated significantly with worse knee OA symptoms for total WOMAC score (pvalue< 0.001, r = 0.643). There was a significant association between 2D:4D ratio and Body Mass Index (BMI) (F-stat (df) 4.38 (2), P-value 0.015) and higher BMI majority in type II (mean (SD) 30.2 (4.31)). Conclusion: There is no association between WOMAC score and 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. It means that different type of finger pattern does not affect the severity of physical disability. However, the study showed positive correlation between total WOMAC score and higher Body Mass Index (BMI) and significant association between 2D:4D ratio and higher Body Mass Index (BMI). Those with higher Body Mass Index (BMI) majority in type II
format	Thesis
qualification_level	Master's degree
author	Amir, Nurul Fakhri
author_facet	Amir, Nurul Fakhri
author_sort	Amir, Nurul Fakhri
title	Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_short	Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_full	Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_fullStr	Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_full_unstemmed	Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_sort	association between womac score and 2d:4d ration in women with knee osteoarthritis
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42541/1/Dr._Nurul_Fakhri_Amir-24_pages.pdf
_version_	1747821081919488000

Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis

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