Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats

Alterations of cardiovascular reflexes in diabetes contribute to the increased cardiovascular morbidity and mortality. These alterations may be mediated at the level of afferent nerves, central baroreflex or efferent nerves within the baroreflex circuitry. Using the streptozotocin (STZ)-induced diab...

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Main Author:	Hassan, Zurina
Format:	Thesis
Language:	English
Published:	2012
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/42894/1/ZURINA_HASSAN.pdf
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id	my-usm-ep.42894
record_format	uketd_dc
spelling	my-usm-ep.428942019-04-12T05:26:22Z Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats 2012-04 Hassan, Zurina RS1-441 Pharmacy and materia medica Alterations of cardiovascular reflexes in diabetes contribute to the increased cardiovascular morbidity and mortality. These alterations may be mediated at the level of afferent nerves, central baroreflex or efferent nerves within the baroreflex circuitry. Using the streptozotocin (STZ)-induced diabetic rats, the current study was designed to: (1) examine systematically diabetes-induced alteration of the multiple neural components by investigating the afferent nerves of the baroreceptor reflex, contribution of the central baroreflex in the rostral ventrolateral medulla (RVLM) and paraventricular nucleus (PVN) and distribution of activated neurons (c-Fos) in response to baroreceptor activation; (2) evaluate the vascular responsiveness of the diabetic pithed rats in the absence of baroreflex; and (3) examine the potential cellular mechanisms in isolated in vitro aortic rings that may contribute to vascular dysfunction. 2012-04 Thesis http://eprints.usm.my/42894/ http://eprints.usm.my/42894/1/ZURINA_HASSAN.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Hassan, Zurina Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats
description	Alterations of cardiovascular reflexes in diabetes contribute to the increased cardiovascular morbidity and mortality. These alterations may be mediated at the level of afferent nerves, central baroreflex or efferent nerves within the baroreflex circuitry. Using the streptozotocin (STZ)-induced diabetic rats, the current study was designed to: (1) examine systematically diabetes-induced alteration of the multiple neural components by investigating the afferent nerves of the baroreceptor reflex, contribution of the central baroreflex in the rostral ventrolateral medulla (RVLM) and paraventricular nucleus (PVN) and distribution of activated neurons (c-Fos) in response to baroreceptor activation; (2) evaluate the vascular responsiveness of the diabetic pithed rats in the absence of baroreflex; and (3) examine the potential cellular mechanisms in isolated in vitro aortic rings that may contribute to vascular dysfunction.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Hassan, Zurina
author_facet	Hassan, Zurina
author_sort	Hassan, Zurina
title	Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats
title_short	Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats
title_full	Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats
title_fullStr	Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats
title_full_unstemmed	Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats
title_sort	changes in central and peripheral regulation of streptozotocin-induced diabetic rats
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2012
url	http://eprints.usm.my/42894/1/ZURINA_HASSAN.pdf
_version_	1747821121758035968

Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats

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