Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity

Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity

Four zinc complexes of the formulae Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)NH2}2 (V), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H) CH3}2∙CH3OH (VI), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C2H5}2 (VII), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C6H5}2∙H2O (VIII) have been synthesised and characterised. The struc...

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Main Author: Rajamuthy, Vikneswaran
Format: Thesis
Language:English
Published: 2011
Subjects:
QD1-999 Chemistry
Online Access:http://eprints.usm.my/43516/1/VIKNESWARAN%20RAJAMUTHY.pdf
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spelling my-usm-ep.435162019-04-12T05:26:31Z Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity 2011-08 Rajamuthy, Vikneswaran QD1-999 Chemistry Four zinc complexes of the formulae Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)NH2}2 (V), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H) CH3}2∙CH3OH (VI), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C2H5}2 (VII), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C6H5}2∙H2O (VIII) have been synthesised and characterised. The structures of these complexes have been established by a single-crystal X-ray diffraction analysis. The coordination geometries of the zinc centres are identical, showing a distorted tetrahedral coordination. The complexes are redox active, giving a reversible cyclic voltammetric response of the Fe(III) − Fe(II) couple near 0.5 V vs. Ag/AgCl. The binding constants, Kb, of the complexes for binding with CT DNA are in the range of 7.0 × 102 to 4.8 × 103 M-1. 2011-08 Thesis http://eprints.usm.my/43516/ http://eprints.usm.my/43516/1/VIKNESWARAN%20RAJAMUTHY.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QD1-999 Chemistry
spellingShingle QD1-999 Chemistry
Rajamuthy, Vikneswaran
Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity
description Four zinc complexes of the formulae Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)NH2}2 (V), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H) CH3}2∙CH3OH (VI), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C2H5}2 (VII), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C6H5}2∙H2O (VIII) have been synthesised and characterised. The structures of these complexes have been established by a single-crystal X-ray diffraction analysis. The coordination geometries of the zinc centres are identical, showing a distorted tetrahedral coordination. The complexes are redox active, giving a reversible cyclic voltammetric response of the Fe(III) − Fe(II) couple near 0.5 V vs. Ag/AgCl. The binding constants, Kb, of the complexes for binding with CT DNA are in the range of 7.0 × 102 to 4.8 × 103 M-1.
format Thesis
qualification_level Master's degree
author Rajamuthy, Vikneswaran
author_facet Rajamuthy, Vikneswaran
author_sort Rajamuthy, Vikneswaran
title Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity
title_short Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity
title_full Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity
title_fullStr Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity
title_full_unstemmed Zinc(II) Ferrocenylthiosemicarbazone Complexes: Structure, Electrochemistry, Dna Binding And Nuclease Activity
title_sort zinc(ii) ferrocenylthiosemicarbazone complexes: structure, electrochemistry, dna binding and nuclease activity
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Kimia
publishDate 2011
url http://eprints.usm.my/43516/1/VIKNESWARAN%20RAJAMUTHY.pdf
_version_ 1747821231271313408

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