Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan

Background: Necrotizing fasciitis is a rapidly progressive soft tissue infection involving deep fascia which carries relatively high mortality rate worldwide. The aim of this study is to determine the mortality rate in our local general hospital and to investigate the factors that determine the p...

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Main Author:	Mustapa, Noor Shazlini
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/43620/1/Dr.%20Noor%20Shazlini%20Bt%20Mustapa-24%20pages.pdf
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spelling	my-usm-ep.436202019-04-12T05:25:32Z Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan 2016 Mustapa, Noor Shazlini RE Ophthalmology Background: Necrotizing fasciitis is a rapidly progressive soft tissue infection involving deep fascia which carries relatively high mortality rate worldwide. The aim of this study is to determine the mortality rate in our local general hospital and to investigate the factors that determine the primary outcome (mortality) of the necrotizing fasciitis patients treated in Intensive Care Unit. Methods: This is retrospective cross sectional study involved 71 patients admitted to intensive care unit (ICU) HRPZ II from January 2012 to December 2015. Patients were analyzed for presence of co-morbidities, Acute Physiology and Chronic Health Evaluation (APACHE II score), factors important in pathogenesis and treatment, and mortality. Results: The overall mortality was 22/71(31%). The mean APACHE II score was 19.2 (SD=6.57) and the median time to operation was 50 hours (IQR=70.0). Factors directly contributing towards mortality were higher APACHE II score (adjusted OR 1.41, 95%CI: 1.20, 1.66, P< 0.001) and an increase in time to surgical debridement (adjusted OR 1.03, 95%CI: 1.01, 1.05, P=0.003) Conclusion: Early surgical debridement was crucial in the treating the necrotizing fasciitis. High APACHE 11 score during admission was associated with increase mortality. 2016 Thesis http://eprints.usm.my/43620/ http://eprints.usm.my/43620/1/Dr.%20Noor%20Shazlini%20Bt%20Mustapa-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Mustapa, Noor Shazlini Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
description	Background: Necrotizing fasciitis is a rapidly progressive soft tissue infection involving deep fascia which carries relatively high mortality rate worldwide. The aim of this study is to determine the mortality rate in our local general hospital and to investigate the factors that determine the primary outcome (mortality) of the necrotizing fasciitis patients treated in Intensive Care Unit. Methods: This is retrospective cross sectional study involved 71 patients admitted to intensive care unit (ICU) HRPZ II from January 2012 to December 2015. Patients were analyzed for presence of co-morbidities, Acute Physiology and Chronic Health Evaluation (APACHE II score), factors important in pathogenesis and treatment, and mortality. Results: The overall mortality was 22/71(31%). The mean APACHE II score was 19.2 (SD=6.57) and the median time to operation was 50 hours (IQR=70.0). Factors directly contributing towards mortality were higher APACHE II score (adjusted OR 1.41, 95%CI: 1.20, 1.66, P< 0.001) and an increase in time to surgical debridement (adjusted OR 1.03, 95%CI: 1.01, 1.05, P=0.003) Conclusion: Early surgical debridement was crucial in the treating the necrotizing fasciitis. High APACHE 11 score during admission was associated with increase mortality.
format	Thesis
qualification_level	Master's degree
author	Mustapa, Noor Shazlini
author_facet	Mustapa, Noor Shazlini
author_sort	Mustapa, Noor Shazlini
title	Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_short	Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_full	Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_fullStr	Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_full_unstemmed	Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_sort	retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, hospital raja perempuan zainab ii, kota bharu, kelantan
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/43620/1/Dr.%20Noor%20Shazlini%20Bt%20Mustapa-24%20pages.pdf
_version_	1747821248390365184

Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan

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