Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation

Salmonella Typhi (S. Typhi) is a human-specific pathogen which causes typhoid fever. One major factor contributing to typhoid persistence is the existence of asymptomatic typhoid carriers. Biofilm formation in the human gallbladder is postulated to be associated with development of the carrier-state...

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Main Author:	Dashti, Marjan Ganjali
Format:	Thesis
Language:	English
Published:	2018
Subjects:	QH1 Natural history (General - Including nature conservation geographical distribution)
Online Access:	http://eprints.usm.my/43673/1/MARJAN%20GANJALI%20DASHTI.pdf
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id	my-usm-ep.43673
record_format	uketd_dc
spelling	my-usm-ep.436732019-04-12T05:24:51Z Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation 2018-03 Dashti, Marjan Ganjali QH1 Natural history (General - Including nature conservation, geographical distribution) Salmonella Typhi (S. Typhi) is a human-specific pathogen which causes typhoid fever. One major factor contributing to typhoid persistence is the existence of asymptomatic typhoid carriers. Biofilm formation in the human gallbladder is postulated to be associated with development of the carrier-state. The aim of this study was to develop an optimized assay for S. Typhi biofilm formation in vitro that mimics the environment of the gallbladder. Six key variables involved in S. Typhi biofilm formation were optimized using Response Surface Methodology (RSM), and the resulting assay formed the basis for transcriptomic investigation of biofilm production, in the presence of the antibiotics kanamycin and chloramphenicol. 2018-03 Thesis http://eprints.usm.my/43673/ http://eprints.usm.my/43673/1/MARJAN%20GANJALI%20DASHTI.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1 Natural history (General - Including nature conservation geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation geographical distribution) Dashti, Marjan Ganjali Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation
description	Salmonella Typhi (S. Typhi) is a human-specific pathogen which causes typhoid fever. One major factor contributing to typhoid persistence is the existence of asymptomatic typhoid carriers. Biofilm formation in the human gallbladder is postulated to be associated with development of the carrier-state. The aim of this study was to develop an optimized assay for S. Typhi biofilm formation in vitro that mimics the environment of the gallbladder. Six key variables involved in S. Typhi biofilm formation were optimized using Response Surface Methodology (RSM), and the resulting assay formed the basis for transcriptomic investigation of biofilm production, in the presence of the antibiotics kanamycin and chloramphenicol.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Dashti, Marjan Ganjali
author_facet	Dashti, Marjan Ganjali
author_sort	Dashti, Marjan Ganjali
title	Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation
title_short	Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation
title_full	Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation
title_fullStr	Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation
title_full_unstemmed	Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation
title_sort	transcriptomic response of salmonella enterica subspecies enterica serovar typhi to antibiotic treatments during biofilm formation
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2018
url	http://eprints.usm.my/43673/1/MARJAN%20GANJALI%20DASHTI.pdf
_version_	1747821259620614144

Transcriptomic Response Of Salmonella enterica Subspecies enterica serovar Typhi To Antibiotic Treatments During Biofilm Formation

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