Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma

Prostaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essent...

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Main Author:	Khare, Vani
Format:	Thesis
Language:	English
Published:	2013
Subjects:	QH1 Natural history (General - Including nature conservation geographical distribution)
Online Access:	http://eprints.usm.my/43997/1/Vani%20Khare.pdf
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id	my-usm-ep.43997
record_format	uketd_dc
spelling	my-usm-ep.439972019-04-12T05:26:18Z Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma 2013-02 Khare, Vani QH1 Natural history (General - Including nature conservation, geographical distribution) Prostaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essential for the production of prostaglandin during various stages of oogenesis, such as oocyte growth, maturation and ovulation. In comparison to COX-2, there is a paucity of knowledge on the role of COX-1, especially in oogenesis. At the same time, while COX-2 is a well established marker in ovulation, its function in growth and maturation of oocyte requires further exploration. This study, thereby, distinguishes the role of COX-1 and COX-2 during zebrafish oocyte growth and maturation, firstly by examining the mRNA expression of both the isoforms in these oocyte stages. An increase in zebrafish follicle COX-1 mRNA expression was observed as the oocytes develop and mature. 2013-02 Thesis http://eprints.usm.my/43997/ http://eprints.usm.my/43997/1/Vani%20Khare.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1 Natural history (General - Including nature conservation geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation geographical distribution) Khare, Vani Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
description	Prostaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essential for the production of prostaglandin during various stages of oogenesis, such as oocyte growth, maturation and ovulation. In comparison to COX-2, there is a paucity of knowledge on the role of COX-1, especially in oogenesis. At the same time, while COX-2 is a well established marker in ovulation, its function in growth and maturation of oocyte requires further exploration. This study, thereby, distinguishes the role of COX-1 and COX-2 during zebrafish oocyte growth and maturation, firstly by examining the mRNA expression of both the isoforms in these oocyte stages. An increase in zebrafish follicle COX-1 mRNA expression was observed as the oocytes develop and mature.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Khare, Vani
author_facet	Khare, Vani
author_sort	Khare, Vani
title	Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_short	Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_full	Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_fullStr	Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_full_unstemmed	Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma
title_sort	role of cyclooxygenases in zebrafish oogenesis and their transcriptional regulation by peroxisome proliferator activated receptor gamma
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2013
url	http://eprints.usm.my/43997/1/Vani%20Khare.pdf
_version_	1747821315744595968

Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma

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