Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application

Nombor atom tinggi (Z) nanopartikel bismut oksida (Bi2O3 NPs) mempunyai penembusan sel yang lebih banyak dan kurang kesan buruk daripada pemeka sinaran konvensional. Pelbagai saiz Bi2O3 NPs telah berjaya dihasilkan dengan menggunakan kaedah hidroterma dan digunakan untuk aplikasi radioterapi. Bebera...

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Main Author:	Zulkifli, Zulfa Aiza
Format:	Thesis
Language:	English
Published:	2018
Subjects:	T Technology TN799.5-948 Nonmetallic minerals
Online Access:	http://eprints.usm.my/44264/1/Synthesis%20Of%20Bismuth%20Oxide%20Nanoparticles%20For%20Radiotherapy%20Application.pdf
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spelling	my-usm-ep.442642019-05-06T02:38:51Z Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application 2018-06 Zulkifli, Zulfa Aiza T Technology TN799.5-948 Nonmetallic minerals Nombor atom tinggi (Z) nanopartikel bismut oksida (Bi2O3 NPs) mempunyai penembusan sel yang lebih banyak dan kurang kesan buruk daripada pemeka sinaran konvensional. Pelbagai saiz Bi2O3 NPs telah berjaya dihasilkan dengan menggunakan kaedah hidroterma dan digunakan untuk aplikasi radioterapi. Beberapa sintesis parameter telah dikaji: kesan perbezaan suhu dan kesan perbezaan masa hidroterma, kesan perbezaan kepekatan bismuth nitrat, Bi(NO3)3, dan, kesan perbezaan kepekatan polietilena glikol (PEG). Sifat-sifat Bi2O3 NPs telah dikaji untuk menentukan kehadiran fasa, penghabluran, morfologi, kehadiran unsur dan saiz partikel. Analisa XRD membuktikan Bi2O3 tulen dengan fasa monoklinik telah dihasilkan (Kod Rujukan ICDD: 98-000-6260). Saiz Bi2O3 NPs didapati meningkat dengan peningkatan suhu dan masa tindakbalas hidrotherma. Walaubagaimanapun, apabila kepekatan Bi(NO3)3 meningkat, saiz partikel Bi2O3 NPs menurun disebabkan oleh kurangnya resapan ion ke dalam nucleus. Pemerhatian terhadap morphologi menunjukkan Bi2O3 NPs berbentuk rod. Nanopartikel yang disalut dengan PEG tidak menunjukkan sebarang peningkatan saiz. Berdasarkan analisa FTIR, keamatan Bi2O3 NPs berkurang apabila kepekatan PEG meningkat kerana molekul PEG dapat diserap ke permukaan kristal Bi melalui ikatan Bi–O. Bi2O3 NPs yang dihasilkan kemudiannya menjalani kajian ketoksikan dan radioterapi. Kajian ketoksikan terhadap Bi2O3 NPs tidak memberi kesan toksik kepada sel barah payudara (mcf-7) pada kepekatan 0.05 μM - 50 μM. Prestasi radioterapi oleh Bi2O3 NPs yang telah dihasilkan diperoleh dengan mengira nisbah peningkatan pemekaan (SER). Akhirnya, 60 nm Bi2O3 NPs diperolehi sebagai keputusan yang optimum dengan SER 1.26. _______________________________________________________________________________________________________ High atomic number (Z) of bismuth oxide nanoparticles (Bi2O3 NPs) has more cell penetration and less adverse effects than conventional radiosensitisers. In this work, various sizes of Bi2O3 NPs were successfully synthesised using hydrothermal method. Several synthesis parameters were studied: effect of hydrothermal reaction temperature, effect of hydrothermal reaction time, effect of bismuth nitrate, Bi(NO3)3 concentration and effect of polyethylene glycol (PEG) concentration. The properties of Bi2O3 NPs were then characterised to determine the phase presence, crystallinity, morphology, elemental presence and size of nanoparticles. The as-synthesised Bi2O3 NPs was in monoclinic Bi2O3 phase (ICDD 98-008-5622). Increasing reaction temperature and time increased the size of Bi2O3 NPs. However, as the Bi(NO3)3 concentration increased, the particle size of Bi2O3 NPs decreased due to less ions diffusion per nuclei. The morphology observation showed that Bi2O3 NPs were in rods form. Coating with PEG did not show any increase in nanoparticles size. Based on Fourier-transform infrared spectroscopy (FTIR) analysis, by increasing the PEG concentration, the intensity of Bi2O3 NPs band diminished because PEG molecules could adsorb onto the surface of Bi crystals through Bi–O bonding. After that, the produced Bi2O3 NPs were subjected to cytotoxicity analysis and radiotherapy. Bi2O3 NPs did not induce cytotoxicity in breast cancer (mcf-7) cell lines at concentration from 0.05 μM to 50 μM. The radiotherapy performance of the as-prepared Bi2O3 NPs was obtained by calculating the sensitisation enhancement ratio (SER). The optimum result was obtained for 60 nm Bi2O3 NPs with SER of 1.26. 2018-06 Thesis http://eprints.usm.my/44264/ http://eprints.usm.my/44264/1/Synthesis%20Of%20Bismuth%20Oxide%20Nanoparticles%20For%20Radiotherapy%20Application.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology TN799.5-948 Nonmetallic minerals
spellingShingle	T Technology TN799.5-948 Nonmetallic minerals Zulkifli, Zulfa Aiza Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application
description	Nombor atom tinggi (Z) nanopartikel bismut oksida (Bi2O3 NPs) mempunyai penembusan sel yang lebih banyak dan kurang kesan buruk daripada pemeka sinaran konvensional. Pelbagai saiz Bi2O3 NPs telah berjaya dihasilkan dengan menggunakan kaedah hidroterma dan digunakan untuk aplikasi radioterapi. Beberapa sintesis parameter telah dikaji: kesan perbezaan suhu dan kesan perbezaan masa hidroterma, kesan perbezaan kepekatan bismuth nitrat, Bi(NO3)3, dan, kesan perbezaan kepekatan polietilena glikol (PEG). Sifat-sifat Bi2O3 NPs telah dikaji untuk menentukan kehadiran fasa, penghabluran, morfologi, kehadiran unsur dan saiz partikel. Analisa XRD membuktikan Bi2O3 tulen dengan fasa monoklinik telah dihasilkan (Kod Rujukan ICDD: 98-000-6260). Saiz Bi2O3 NPs didapati meningkat dengan peningkatan suhu dan masa tindakbalas hidrotherma. Walaubagaimanapun, apabila kepekatan Bi(NO3)3 meningkat, saiz partikel Bi2O3 NPs menurun disebabkan oleh kurangnya resapan ion ke dalam nucleus. Pemerhatian terhadap morphologi menunjukkan Bi2O3 NPs berbentuk rod. Nanopartikel yang disalut dengan PEG tidak menunjukkan sebarang peningkatan saiz. Berdasarkan analisa FTIR, keamatan Bi2O3 NPs berkurang apabila kepekatan PEG meningkat kerana molekul PEG dapat diserap ke permukaan kristal Bi melalui ikatan Bi–O. Bi2O3 NPs yang dihasilkan kemudiannya menjalani kajian ketoksikan dan radioterapi. Kajian ketoksikan terhadap Bi2O3 NPs tidak memberi kesan toksik kepada sel barah payudara (mcf-7) pada kepekatan 0.05 μM - 50 μM. Prestasi radioterapi oleh Bi2O3 NPs yang telah dihasilkan diperoleh dengan mengira nisbah peningkatan pemekaan (SER). Akhirnya, 60 nm Bi2O3 NPs diperolehi sebagai keputusan yang optimum dengan SER 1.26. _______________________________________________________________________________________________________ High atomic number (Z) of bismuth oxide nanoparticles (Bi2O3 NPs) has more cell penetration and less adverse effects than conventional radiosensitisers. In this work, various sizes of Bi2O3 NPs were successfully synthesised using hydrothermal method. Several synthesis parameters were studied: effect of hydrothermal reaction temperature, effect of hydrothermal reaction time, effect of bismuth nitrate, Bi(NO3)3 concentration and effect of polyethylene glycol (PEG) concentration. The properties of Bi2O3 NPs were then characterised to determine the phase presence, crystallinity, morphology, elemental presence and size of nanoparticles. The as-synthesised Bi2O3 NPs was in monoclinic Bi2O3 phase (ICDD 98-008-5622). Increasing reaction temperature and time increased the size of Bi2O3 NPs. However, as the Bi(NO3)3 concentration increased, the particle size of Bi2O3 NPs decreased due to less ions diffusion per nuclei. The morphology observation showed that Bi2O3 NPs were in rods form. Coating with PEG did not show any increase in nanoparticles size. Based on Fourier-transform infrared spectroscopy (FTIR) analysis, by increasing the PEG concentration, the intensity of Bi2O3 NPs band diminished because PEG molecules could adsorb onto the surface of Bi crystals through Bi–O bonding. After that, the produced Bi2O3 NPs were subjected to cytotoxicity analysis and radiotherapy. Bi2O3 NPs did not induce cytotoxicity in breast cancer (mcf-7) cell lines at concentration from 0.05 μM to 50 μM. The radiotherapy performance of the as-prepared Bi2O3 NPs was obtained by calculating the sensitisation enhancement ratio (SER). The optimum result was obtained for 60 nm Bi2O3 NPs with SER of 1.26.
format	Thesis
qualification_level	Master's degree
author	Zulkifli, Zulfa Aiza
author_facet	Zulkifli, Zulfa Aiza
author_sort	Zulkifli, Zulfa Aiza
title	Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application
title_short	Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application
title_full	Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application
title_fullStr	Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application
title_full_unstemmed	Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application
title_sort	synthesis of bismuth oxide nanoparticles for radiotherapy application
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
publishDate	2018
url	http://eprints.usm.my/44264/1/Synthesis%20Of%20Bismuth%20Oxide%20Nanoparticles%20For%20Radiotherapy%20Application.pdf
_version_	1747821350439878656

Synthesis Of Bismuth Oxide Nanoparticles For Radiotherapy Application

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