Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid

Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid

The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen ac...

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Main Author: Gonawan, Fadzil Noor
Format: Thesis
Language:English
Published: 2012
Subjects:
TP1-1185 Chemical technology
Online Access:http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf
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spelling my-usm-ep.448012019-07-02T01:19:25Z Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid 2012-06 Gonawan, Fadzil Noor TP1-1185 Chemical technology The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen acid. Moreover, the hydrolysis process shows an optimum performance at only 2% (v/v) dimethyl sulfoxide (DMSO) and at the reaction temperature of 30°C. The addition of 2% (v/v) DMSO has increased the conversion of substrate and further increase in the concentration of DMSO has resulted in a low initial reaction rate and conversion of substrate, however gives a high enantiomeric excess of the product (eeP). 2012-06 Thesis http://eprints.usm.my/44801/ http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuteraan Kimia
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic TP1-1185 Chemical technology
spellingShingle TP1-1185 Chemical technology
Gonawan, Fadzil Noor
Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
description The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen acid. Moreover, the hydrolysis process shows an optimum performance at only 2% (v/v) dimethyl sulfoxide (DMSO) and at the reaction temperature of 30°C. The addition of 2% (v/v) DMSO has increased the conversion of substrate and further increase in the concentration of DMSO has resulted in a low initial reaction rate and conversion of substrate, however gives a high enantiomeric excess of the product (eeP).
format Thesis
qualification_level Master's degree
author Gonawan, Fadzil Noor
author_facet Gonawan, Fadzil Noor
author_sort Gonawan, Fadzil Noor
title Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
title_short Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
title_full Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
title_fullStr Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
title_full_unstemmed Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
title_sort kinetics and modelling for the production of (s)-ibuprofen acid
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Kejuteraan Kimia
publishDate 2012
url http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf
_version_ 1747821401971097600

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