Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial

BACKGROUND Allergic rhinitis is an IgE-mediated inflammation of the nasal mucosa. The management of allergic rhinitis has not changed much and only limited studies has been done to explore the benefit of complementary alternative therapy. Honey is proven in its anti-inflammatory, antibacterial a...

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Main Author:	Manab, Farah Wahida Abd
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RF Otorhinolaryngology
Online Access:	http://eprints.usm.my/44937/1/Dr.%20Farah%20Wahida%20Abd%20Manab-24%20pages.pdf
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spelling	my-usm-ep.449372020-10-22T03:03:14Z Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial 2017 Manab, Farah Wahida Abd RF Otorhinolaryngology BACKGROUND Allergic rhinitis is an IgE-mediated inflammation of the nasal mucosa. The management of allergic rhinitis has not changed much and only limited studies has been done to explore the benefit of complementary alternative therapy. Honey is proven in its anti-inflammatory, antibacterial and anti-oxidant properties and found to be useful for treatment of inflammation. We aimed to determine the efficacy of honey nasal spray as an adjunct treatment of moderate to severe persistent allergic rhinitis. METHOD Patients were recruited from our Otorhinolaryngology- Head & Neck Surgery Clinic from November 2015 to July 2016. Thirty moderate to severe persistent allergic rhinitis patients with positive skin prick tests were divided randomly into control and trial group. Both groups received standard medication (intranasal corticosteroids and oral antihistamines). In addition, the trial group received honey nasal spray as adjunctive daily dose. Patients were assessedusing SNOT22 questionnaires at 0, 2nd and 6th weeks of the study with the focus on the primary symptoms of nasal blockage, rhinorrhea and sneezing RESULTS There was overall improvement of total SNOT 22 score and each symptom score of nasal blockage, rhinorrhea and sneezing together with the total serum IgE level in both groups at the end of 6 weeks. However, the improvement was seen more consistently in the trial group as evidenced by the reduction of estimated means score of all measured outcomes. CONCLUSION The honey nasal spray has beneficial effect as an adjunct treatment in moderate to severe persistent allergic rhinitis by acting as a protective mucous layer in reducing the attachment of allergen to the nasal mucosa. 2017 Thesis http://eprints.usm.my/44937/ http://eprints.usm.my/44937/1/Dr.%20Farah%20Wahida%20Abd%20Manab-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RF Otorhinolaryngology
spellingShingle	RF Otorhinolaryngology Manab, Farah Wahida Abd Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial
description	BACKGROUND Allergic rhinitis is an IgE-mediated inflammation of the nasal mucosa. The management of allergic rhinitis has not changed much and only limited studies has been done to explore the benefit of complementary alternative therapy. Honey is proven in its anti-inflammatory, antibacterial and anti-oxidant properties and found to be useful for treatment of inflammation. We aimed to determine the efficacy of honey nasal spray as an adjunct treatment of moderate to severe persistent allergic rhinitis. METHOD Patients were recruited from our Otorhinolaryngology- Head & Neck Surgery Clinic from November 2015 to July 2016. Thirty moderate to severe persistent allergic rhinitis patients with positive skin prick tests were divided randomly into control and trial group. Both groups received standard medication (intranasal corticosteroids and oral antihistamines). In addition, the trial group received honey nasal spray as adjunctive daily dose. Patients were assessedusing SNOT22 questionnaires at 0, 2nd and 6th weeks of the study with the focus on the primary symptoms of nasal blockage, rhinorrhea and sneezing RESULTS There was overall improvement of total SNOT 22 score and each symptom score of nasal blockage, rhinorrhea and sneezing together with the total serum IgE level in both groups at the end of 6 weeks. However, the improvement was seen more consistently in the trial group as evidenced by the reduction of estimated means score of all measured outcomes. CONCLUSION The honey nasal spray has beneficial effect as an adjunct treatment in moderate to severe persistent allergic rhinitis by acting as a protective mucous layer in reducing the attachment of allergen to the nasal mucosa.
format	Thesis
qualification_level	Master's degree
author	Manab, Farah Wahida Abd
author_facet	Manab, Farah Wahida Abd
author_sort	Manab, Farah Wahida Abd
title	Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial
title_short	Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial
title_full	Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial
title_fullStr	Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial
title_full_unstemmed	Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial
title_sort	efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2017
url	http://eprints.usm.my/44937/1/Dr.%20Farah%20Wahida%20Abd%20Manab-24%20pages.pdf
_version_	1747821428475953152

Efficacy of honey nasal spray as an adjunct treatment for allergic rhinitis : a randomized controlled trial

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