Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans

Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans

Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would...

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Main Author: Cheah, Hong Leong
Format: Thesis
Language:English
Published: 2014
Subjects:
R735-854 Medical education
Medical schools
Research
Online Access:http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf
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spelling my-usm-ep.449922019-07-22T02:57:10Z Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans 2014-06 Cheah, Hong Leong R735-854 Medical education. Medical schools. Research Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would be an attractive antifungal drug target for C. albicans. In this study, an alternative cell-based screening approach that better reflect the physiological environment in host system was employed to identify lead compounds that inhibit the glyoxylate cycle. 2014-06 Thesis http://eprints.usm.my/44992/ http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf application/pdf en public masters Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R735-854 Medical education
Medical schools
Research
spellingShingle R735-854 Medical education
Medical schools
Research
Cheah, Hong Leong
Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
description Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would be an attractive antifungal drug target for C. albicans. In this study, an alternative cell-based screening approach that better reflect the physiological environment in host system was employed to identify lead compounds that inhibit the glyoxylate cycle.
format Thesis
qualification_level Master's degree
author Cheah, Hong Leong
author_facet Cheah, Hong Leong
author_sort Cheah, Hong Leong
title Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_short Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_full Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_fullStr Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_full_unstemmed Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_sort screening and characterisation of inhibitors for glyoxylate cycle icl enzyme activity in candida albicans
granting_institution Universiti Sains Malaysia
granting_department Institut Perubatan & Pergigian Termaju
publishDate 2014
url http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf
_version_ 1747821433848856576

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