Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014

Background: The AIDS death is still a worldwide concern as well as in Kelantan. However, the median survival time and predictor factors that contributing to risk of death among AIDS patients in Kelantan were unknown. Objectives: To determine the overall median survival time and survival rate of A...

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Main Author:	Ngah, Hamiza
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RA643-645 Disease (Communicable and noninfectious) and public health
Online Access:	http://eprints.usm.my/45899/1/Dr.%20Hamiza%20Ngah-24%20pages.pdf
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spelling	my-usm-ep.458992020-01-15T07:32:17Z Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014 2018-05 Ngah, Hamiza RA643-645 Disease (Communicable and noninfectious) and public health Background: The AIDS death is still a worldwide concern as well as in Kelantan. However, the median survival time and predictor factors that contributing to risk of death among AIDS patients in Kelantan were unknown. Objectives: To determine the overall median survival time and survival rate of AIDS patients and predictors factors of death in Kelantan population from 2010 to 2014. Methodology: A retrospective cohort study was conducted in January 2018 using secondary data obtained from National AIDS Registry for the period of 1st January 2010 to 31st December 2014 and followed-up until 31st Mac 2015. A complete 1073 data was selected for descriptive analysis and survival analysis. Kaplan- Meier survival analysis and Cox’s proportional hazard regression model with estimates of hazard ratio and 95% confidence interval were used. Result: The mean (SD) age was 37.08 (7.37). The patients were predominantly males (87.0%), Malays (87.5%), single (62.3%), unemployed (38.0%), with background of secondary education (78.1%) and cases without HIV-TB co-infection (62.8%). Approximately 53% of the patients death during follow-up. The overall median survival time was 11 months. The probability of survival in 1-year, 2-year and 5-year were 49.1%, 47.8%, and 46.7% respectively. Multivariate Cox regression showed that significant prognostic factors were age 30-49 years (Adj. HR 1.57; 95% CI: 1.14, 2.16; p=0.006), male (Adj. HR 1.39; 95% CI: 1.07, 1.79; p=0.012), unemployed (Adj. HR1.40; 95% CI: 1.12, 1.75; p=0.003) and HIV-TB co-infection (Adj. HR 1.78; 95% CI: 1.37, 2.31; p<0.001). Conclusion: The overall median survival time among AIDS patients in Kelantan was still low. To increase the survival among AIDS patients, every effort need to be made to ensure early screening, early diagnosis, early intervention and comprehensive management involving initiating HAART treatment as soon as possible in treating HIV/AIDS patients before they progress to AIDS-related death. 2018-05 Thesis http://eprints.usm.my/45899/ http://eprints.usm.my/45899/1/Dr.%20Hamiza%20Ngah-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RA643-645 Disease (Communicable and noninfectious) and public health
spellingShingle	RA643-645 Disease (Communicable and noninfectious) and public health Ngah, Hamiza Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
description	Background: The AIDS death is still a worldwide concern as well as in Kelantan. However, the median survival time and predictor factors that contributing to risk of death among AIDS patients in Kelantan were unknown. Objectives: To determine the overall median survival time and survival rate of AIDS patients and predictors factors of death in Kelantan population from 2010 to 2014. Methodology: A retrospective cohort study was conducted in January 2018 using secondary data obtained from National AIDS Registry for the period of 1st January 2010 to 31st December 2014 and followed-up until 31st Mac 2015. A complete 1073 data was selected for descriptive analysis and survival analysis. Kaplan- Meier survival analysis and Cox’s proportional hazard regression model with estimates of hazard ratio and 95% confidence interval were used. Result: The mean (SD) age was 37.08 (7.37). The patients were predominantly males (87.0%), Malays (87.5%), single (62.3%), unemployed (38.0%), with background of secondary education (78.1%) and cases without HIV-TB co-infection (62.8%). Approximately 53% of the patients death during follow-up. The overall median survival time was 11 months. The probability of survival in 1-year, 2-year and 5-year were 49.1%, 47.8%, and 46.7% respectively. Multivariate Cox regression showed that significant prognostic factors were age 30-49 years (Adj. HR 1.57; 95% CI: 1.14, 2.16; p=0.006), male (Adj. HR 1.39; 95% CI: 1.07, 1.79; p=0.012), unemployed (Adj. HR1.40; 95% CI: 1.12, 1.75; p=0.003) and HIV-TB co-infection (Adj. HR 1.78; 95% CI: 1.37, 2.31; p<0.001). Conclusion: The overall median survival time among AIDS patients in Kelantan was still low. To increase the survival among AIDS patients, every effort need to be made to ensure early screening, early diagnosis, early intervention and comprehensive management involving initiating HAART treatment as soon as possible in treating HIV/AIDS patients before they progress to AIDS-related death.
format	Thesis
qualification_level	Master's degree
author	Ngah, Hamiza
author_facet	Ngah, Hamiza
author_sort	Ngah, Hamiza
title	Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_short	Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_full	Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_fullStr	Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_full_unstemmed	Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_sort	survival time and prognostic factors of aids patients in kelantan : 2010-2014
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/45899/1/Dr.%20Hamiza%20Ngah-24%20pages.pdf
_version_	1747821586222678016

Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014

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