Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study

Statin, a cholesterol lowering agent, is widely used for treatment of hyperlipidemia (HPL) nowadays. Generally, statin is effective in reducing cholesterol level. However, there is a marked inter-patient variation with regard to response to statin treatment possibly due to differences in patients...

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Main Author:	Rahman, Ilani Ab
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/45922/1/Dr.%20Ilani%20Ab%20Rahman-24%20pages.pdf
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spelling	my-usm-ep.459222020-01-19T08:31:16Z Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study 2018 Rahman, Ilani Ab RC31-1245 Internal medicine Statin, a cholesterol lowering agent, is widely used for treatment of hyperlipidemia (HPL) nowadays. Generally, statin is effective in reducing cholesterol level. However, there is a marked inter-patient variation with regard to response to statin treatment possibly due to differences in patients’ genetic makeup, their demographic profiles, and other clinical factors. A single nucleotide polymorphism(SNP) in Cholesteryl Ester Transfer Protein (CETP) Taq1B (rs708272) gene was reported as a promising predictive genetic marker for cholesterol lowering effect in many populations Until now, there is no genetic association study among Malaysian population has been explored the influence of the particular SNP on statin’s cholesterol lowering effects. Hence, we aim to study the association of CETP Taq1B (rs708272) variants together with other clinical factors on cholesterol lowering effect of statin among HPL patients from Hospital Universiti Sains Malaysia (HUSM), Kelantan. This is a retrospective study which involves 81 HPL patients. The details regarding demographic and clinical characteristics of patients were obtained via interview and patient’s medical record. The genotyping of DNA samples of HPL patients were performed by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The results indicate that there were no significant association between patients’ demographic profiles as well as clinical factors and their statin cholesterol lowering effects. Interestingly, variant in CETP Taq1B rs708272 has been associated with statin’s cholesterol lowering effects for a certain degree. In homozygousmutant patient with B2B2 (AA) genotype has higher HDL-C level (P<0.05) than other genotypes (1.39±0.33 vs 1.29±0.32 and 1.26±0.29). The LDL-C and TC level were decreased significantly (P<0.01) in heterozygous variant patient with B1B2 (AG) genotype. While TG level was decreased significantly in B1 carrier. This finding warrants further multicenter investigation to confirm the association of the SNP with regards to the statin effectiveness on both LDL-C and HDL-C profile. 2018 Thesis http://eprints.usm.my/45922/ http://eprints.usm.my/45922/1/Dr.%20Ilani%20Ab%20Rahman-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Rahman, Ilani Ab Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study
description	Statin, a cholesterol lowering agent, is widely used for treatment of hyperlipidemia (HPL) nowadays. Generally, statin is effective in reducing cholesterol level. However, there is a marked inter-patient variation with regard to response to statin treatment possibly due to differences in patients’ genetic makeup, their demographic profiles, and other clinical factors. A single nucleotide polymorphism(SNP) in Cholesteryl Ester Transfer Protein (CETP) Taq1B (rs708272) gene was reported as a promising predictive genetic marker for cholesterol lowering effect in many populations Until now, there is no genetic association study among Malaysian population has been explored the influence of the particular SNP on statin’s cholesterol lowering effects. Hence, we aim to study the association of CETP Taq1B (rs708272) variants together with other clinical factors on cholesterol lowering effect of statin among HPL patients from Hospital Universiti Sains Malaysia (HUSM), Kelantan. This is a retrospective study which involves 81 HPL patients. The details regarding demographic and clinical characteristics of patients were obtained via interview and patient’s medical record. The genotyping of DNA samples of HPL patients were performed by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The results indicate that there were no significant association between patients’ demographic profiles as well as clinical factors and their statin cholesterol lowering effects. Interestingly, variant in CETP Taq1B rs708272 has been associated with statin’s cholesterol lowering effects for a certain degree. In homozygousmutant patient with B2B2 (AA) genotype has higher HDL-C level (P<0.05) than other genotypes (1.39±0.33 vs 1.29±0.32 and 1.26±0.29). The LDL-C and TC level were decreased significantly (P<0.01) in heterozygous variant patient with B1B2 (AG) genotype. While TG level was decreased significantly in B1 carrier. This finding warrants further multicenter investigation to confirm the association of the SNP with regards to the statin effectiveness on both LDL-C and HDL-C profile.
format	Thesis
qualification_level	Master's degree
author	Rahman, Ilani Ab
author_facet	Rahman, Ilani Ab
author_sort	Rahman, Ilani Ab
title	Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study
title_short	Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study
title_full	Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study
title_fullStr	Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study
title_full_unstemmed	Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study
title_sort	analysis of the association between cetp taq1b polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from husm : a pilot study
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/45922/1/Dr.%20Ilani%20Ab%20Rahman-24%20pages.pdf
_version_	1747821588419444736

Analysis of the association between cetp taq1B polymorphism (rs708272) and cholesterol lowering effects among statin users with hyperlipidaemia from HUSM : a pilot study

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