Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb

The hepatoprotective and pharmacology properties of C. xanthorrhiza rhizome extracts were investigated using in vivo and in vitro model assays. Prior to the bioassays, C. xanthorrhiza rhizome ethanolic extract (CXRE) were subjected to liquid-liquid extraction resulting in hexane, ethyl acetate and w...

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Main Author:	Devaraj, Sutha
Format:	Thesis
Language:	English
Published:	2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://eprints.usm.my/45927/1/SUTHA%20DEVARAJ_HJ.pdf
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id	my-usm-ep.45927
record_format	uketd_dc
spelling	my-usm-ep.459272020-01-20T06:33:10Z Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb 2012-02 Devaraj, Sutha RS Pharmacy and materia medica The hepatoprotective and pharmacology properties of C. xanthorrhiza rhizome extracts were investigated using in vivo and in vitro model assays. Prior to the bioassays, C. xanthorrhiza rhizome ethanolic extract (CXRE) were subjected to liquid-liquid extraction resulting in hexane, ethyl acetate and water fractions. Xanthorrhizol was employed as the marker to standardize the CXRE and fractions respectively. The presence of terpenoids, flavonoids, cardiac glycosides and saponin were observed in the standardized CXRE through qualitative phytochemical screening analysis. The acute oral toxicity of standardized CXRE showed an LD50 of greater than 5,000 mg/kg, indicating CXRE is relatively safe for preclinical investigation in animals. Further, the standardized CXRE and its fractions (hexane, ethyl acetate and water) were tested for antioxidant activity. In FRAP, DPPH and ABTS assay, the highest antioxidant activity was found in hexane fraction compared to the CXRE, ethyl acetate fraction and water fractions in line with their total phenolics and flavonoids content. The total phenolics and flavonoids content of hexane fraction were 61.00 mg GAE/g and 92.80 mg CAE/g respectively. The standardized C. xanthorrhiza rhizome hexane fraction (CXRH) at doses 125, 250 and 500 mg/kg was further tested for hepatoprotective activity against CCl4- induced hepatic damage in rats. 2012-02 Thesis http://eprints.usm.my/45927/ http://eprints.usm.my/45927/1/SUTHA%20DEVARAJ_HJ.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-ubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Devaraj, Sutha Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb
description	The hepatoprotective and pharmacology properties of C. xanthorrhiza rhizome extracts were investigated using in vivo and in vitro model assays. Prior to the bioassays, C. xanthorrhiza rhizome ethanolic extract (CXRE) were subjected to liquid-liquid extraction resulting in hexane, ethyl acetate and water fractions. Xanthorrhizol was employed as the marker to standardize the CXRE and fractions respectively. The presence of terpenoids, flavonoids, cardiac glycosides and saponin were observed in the standardized CXRE through qualitative phytochemical screening analysis. The acute oral toxicity of standardized CXRE showed an LD50 of greater than 5,000 mg/kg, indicating CXRE is relatively safe for preclinical investigation in animals. Further, the standardized CXRE and its fractions (hexane, ethyl acetate and water) were tested for antioxidant activity. In FRAP, DPPH and ABTS assay, the highest antioxidant activity was found in hexane fraction compared to the CXRE, ethyl acetate fraction and water fractions in line with their total phenolics and flavonoids content. The total phenolics and flavonoids content of hexane fraction were 61.00 mg GAE/g and 92.80 mg CAE/g respectively. The standardized C. xanthorrhiza rhizome hexane fraction (CXRH) at doses 125, 250 and 500 mg/kg was further tested for hepatoprotective activity against CCl4- induced hepatic damage in rats.
format	Thesis
qualification_level	Master's degree
author	Devaraj, Sutha
author_facet	Devaraj, Sutha
author_sort	Devaraj, Sutha
title	Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb
title_short	Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb
title_full	Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb
title_fullStr	Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb
title_full_unstemmed	Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb
title_sort	hepatoprotective and pharmacology studies of standardized ethanolic extract of curcuma xanthorrhiza roxb
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Penyelidikan Dadah dan Ubat-ubatan
publishDate	2012
url	http://eprints.usm.my/45927/1/SUTHA%20DEVARAJ_HJ.pdf
_version_	1747821588677394432

Hepatoprotective And Pharmacology Studies Of Standardized Ethanolic Extract Of Curcuma Xanthorrhiza Roxb

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