Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy

Objective: The purpose of this study is to determine volumetry values of the Hippocampal Formation in refractory Temporal Lobe Epilepsy patients comparing with volumetry values of normal individual, correlating the volumetry values with ADC (Apparent Diffusion Coefficient) values for detecting h...

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Main Author:	Amran, Mohd Hanif
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/46462/1/Dr.%20Mohd%20Hanif%20Amran-24%20pages.pdf
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spelling	my-usm-ep.464622020-03-08T03:50:23Z Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy 2018 Amran, Mohd Hanif RC31-1245 Internal medicine Objective: The purpose of this study is to determine volumetry values of the Hippocampal Formation in refractory Temporal Lobe Epilepsy patients comparing with volumetry values of normal individual, correlating the volumetry values with ADC (Apparent Diffusion Coefficient) values for detecting hippocampal formation abnormalities in patients with medically intractable temporal lobe epilepsy (MITLE). Other than that is to correlate MR volumetry values with duration of illness in refractory Temporal Lobe Epilepsy (TLE) patients. Background: In this study, we compared the hippocampal volume of patients with underlying medically intractable temporal lobe epilepsy (MITLE) and normal subjects and to look for correlation between the hippocampal volume, ADC values and duration of illness. Methodology: A total of 28 participants were recruited for the present study; there were 14 participants in control and TLE-positive group, respectively. MR images were evaluated for hippocampal volumetric calculation and was correlated with ADC maps and duration of illness. Mean and SDs were obtained for each measurement, and level of significance was determined. Analysis of mean volumetry, ADC values were performed using PASW version 18. We used an independent t-test to investigate group differences in mean hippocampal volumetric value. Pearson correlation was used to examine relationships between mean hippocampal volumetric value and duration of illness, also as mean hippocampal volumetric value with ADC value. Results: There was no significant difference shown between the left and right hippocampal MR volumetric values in the control group. However, significant differences were shown in hippocampal MR volumetric values, were found between control and TLE-ipsilateral sites. There are also significant differences were shown in hippocampal volumetric values, were found between both sides of hippocampus in right and left TLE patients. The hippocampal MR volumetric values did not show significant correlation with the duration of illness. There was significant correlation between hippocampal volumetric value and ADC. Conclusions: Hippocampal volumetry have the capabilities to detect changes in the hippocampal formation and to lateralize the seizure focus in patients with TLE. There is no significant correlation between hippocampal volumetric values with duration of illness. There was significant correlation between hippocampal volumetric values with ADC. 2018 Thesis http://eprints.usm.my/46462/ http://eprints.usm.my/46462/1/Dr.%20Mohd%20Hanif%20Amran-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Amran, Mohd Hanif Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy
description	Objective: The purpose of this study is to determine volumetry values of the Hippocampal Formation in refractory Temporal Lobe Epilepsy patients comparing with volumetry values of normal individual, correlating the volumetry values with ADC (Apparent Diffusion Coefficient) values for detecting hippocampal formation abnormalities in patients with medically intractable temporal lobe epilepsy (MITLE). Other than that is to correlate MR volumetry values with duration of illness in refractory Temporal Lobe Epilepsy (TLE) patients. Background: In this study, we compared the hippocampal volume of patients with underlying medically intractable temporal lobe epilepsy (MITLE) and normal subjects and to look for correlation between the hippocampal volume, ADC values and duration of illness. Methodology: A total of 28 participants were recruited for the present study; there were 14 participants in control and TLE-positive group, respectively. MR images were evaluated for hippocampal volumetric calculation and was correlated with ADC maps and duration of illness. Mean and SDs were obtained for each measurement, and level of significance was determined. Analysis of mean volumetry, ADC values were performed using PASW version 18. We used an independent t-test to investigate group differences in mean hippocampal volumetric value. Pearson correlation was used to examine relationships between mean hippocampal volumetric value and duration of illness, also as mean hippocampal volumetric value with ADC value. Results: There was no significant difference shown between the left and right hippocampal MR volumetric values in the control group. However, significant differences were shown in hippocampal MR volumetric values, were found between control and TLE-ipsilateral sites. There are also significant differences were shown in hippocampal volumetric values, were found between both sides of hippocampus in right and left TLE patients. The hippocampal MR volumetric values did not show significant correlation with the duration of illness. There was significant correlation between hippocampal volumetric value and ADC. Conclusions: Hippocampal volumetry have the capabilities to detect changes in the hippocampal formation and to lateralize the seizure focus in patients with TLE. There is no significant correlation between hippocampal volumetric values with duration of illness. There was significant correlation between hippocampal volumetric values with ADC.
format	Thesis
qualification_level	Master's degree
author	Amran, Mohd Hanif
author_facet	Amran, Mohd Hanif
author_sort	Amran, Mohd Hanif
title	Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy
title_short	Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy
title_full	Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy
title_fullStr	Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy
title_full_unstemmed	Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy
title_sort	correlation between magnetic resonance (mr) volumetry and apparent diffusion coefficient (adc) value of hippocampal formation in medically intractable temporal lobe epilepsy
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/46462/1/Dr.%20Mohd%20Hanif%20Amran-24%20pages.pdf
_version_	1747821676396019712

Correlation between Magnetic Resonance (MR) Volumetry and Apparent Diffusion Coefficient (ADC) Value of Hippocampal Formation in Medically Intractable Temporal Lobe Epilepsy

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