Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia

Introduction Upper Gastrointestinal Bleeding (UGIB) requiring endoscopic intervention is a common scenario in hospitals. However, not all patients require emergency or urgent endoscopy to be done. This study will validate and associate Glasgow-Blatchford Score (GBS) with Forrest classification. Thi...

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Main Author:	Yusof, Mohd Razaleigh
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC799-869 Diseases of the digestive system Gastroenterology
Online Access:	http://eprints.usm.my/46571/1/Dr.%20Mohd%20Razaleigh%20Yusof-24%20pages.pdf
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id	my-usm-ep.46571
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spelling	my-usm-ep.465712020-06-14T01:47:41Z Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia 2018 Yusof, Mohd Razaleigh RC799-869 Diseases of the digestive system. Gastroenterology Introduction Upper Gastrointestinal Bleeding (UGIB) requiring endoscopic intervention is a common scenario in hospitals. However, not all patients require emergency or urgent endoscopy to be done. This study will validate and associate Glasgow-Blatchford Score (GBS) with Forrest classification. This is to predict the severity of Non-Variceal Upper Gastro Intestinal Bleed according to Glasgow Blatchford Score and validate this scoring system in Hospital Universiti Sains Malaysia. This study will also associate between two scoring system of Glasgow Blatchford Score and Forrest Classification between Non-variceal high risk bleeding with major bleed and non-variceal low risk bleeding with minor bleed. Methodology Data collected from June 2016 till February 2017, 113 patients with Non-variceal bleed underwent emergency OGDS were retrospectively reviewed and were stratified according to Glasgow Blatchford Score to high and low risk. This stratified risk is associated with Forrest classification to determine its endoscopic findings. Results Majority are in the high risk group 107 (94.7%) patients and low risk group 6 (5.3%) patients. Patients in the low risk group was followed up for 30 days and showed no complications or mortality. This study showed patients has a median score of 10.27±3.54. From the data analysis of Glasgow Blatchford Score showed 95.45% sensitivity and 5.49% specificity. Endoscopic findings showed 22 (19.5%) patients had major bleed and 91 (80.5%) patients had minor bleed. Using Fischer Exact Test, there is no significant association between risk and outcome (p-value > 0.950). Conclusion Based on this study alone, we cannot suggest Glasgow Blatchford Score as a predictor for severity of Upper Gastrointestinal Bleeding. This is because as shown in the results, there were no significant association between GBS and Forrest classification. However, this nonsignificant result maybe compounded by several factors as discussed, namely due to underlying Chronic Kidney Disease with anemia, the timing of endoscopy and initiation of medication. With this biases identified, it can be used as a guide in designing and conducting a better study in the future in order to come to a better conclusion about GBS in our population. 2018 Thesis http://eprints.usm.my/46571/ http://eprints.usm.my/46571/1/Dr.%20Mohd%20Razaleigh%20Yusof-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC799-869 Diseases of the digestive system Gastroenterology
spellingShingle	RC799-869 Diseases of the digestive system Gastroenterology Yusof, Mohd Razaleigh Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia
description	Introduction Upper Gastrointestinal Bleeding (UGIB) requiring endoscopic intervention is a common scenario in hospitals. However, not all patients require emergency or urgent endoscopy to be done. This study will validate and associate Glasgow-Blatchford Score (GBS) with Forrest classification. This is to predict the severity of Non-Variceal Upper Gastro Intestinal Bleed according to Glasgow Blatchford Score and validate this scoring system in Hospital Universiti Sains Malaysia. This study will also associate between two scoring system of Glasgow Blatchford Score and Forrest Classification between Non-variceal high risk bleeding with major bleed and non-variceal low risk bleeding with minor bleed. Methodology Data collected from June 2016 till February 2017, 113 patients with Non-variceal bleed underwent emergency OGDS were retrospectively reviewed and were stratified according to Glasgow Blatchford Score to high and low risk. This stratified risk is associated with Forrest classification to determine its endoscopic findings. Results Majority are in the high risk group 107 (94.7%) patients and low risk group 6 (5.3%) patients. Patients in the low risk group was followed up for 30 days and showed no complications or mortality. This study showed patients has a median score of 10.27±3.54. From the data analysis of Glasgow Blatchford Score showed 95.45% sensitivity and 5.49% specificity. Endoscopic findings showed 22 (19.5%) patients had major bleed and 91 (80.5%) patients had minor bleed. Using Fischer Exact Test, there is no significant association between risk and outcome (p-value > 0.950). Conclusion Based on this study alone, we cannot suggest Glasgow Blatchford Score as a predictor for severity of Upper Gastrointestinal Bleeding. This is because as shown in the results, there were no significant association between GBS and Forrest classification. However, this nonsignificant result maybe compounded by several factors as discussed, namely due to underlying Chronic Kidney Disease with anemia, the timing of endoscopy and initiation of medication. With this biases identified, it can be used as a guide in designing and conducting a better study in the future in order to come to a better conclusion about GBS in our population.
format	Thesis
qualification_level	Master's degree
author	Yusof, Mohd Razaleigh
author_facet	Yusof, Mohd Razaleigh
author_sort	Yusof, Mohd Razaleigh
title	Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia
title_short	Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia
title_full	Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia
title_fullStr	Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia
title_full_unstemmed	Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia
title_sort	upper gastrointestinal non-variceal bleeding : validation of glasgow blatchford score and its association with forrest classification in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/46571/1/Dr.%20Mohd%20Razaleigh%20Yusof-24%20pages.pdf
_version_	1747821688123293696

Upper gastrointestinal non-variceal bleeding : validation of Glasgow Blatchford score and its association with Forrest classification in Hospital Universiti Sains Malaysia

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