Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang

Background: Extended storage time lead to storage lesion changes in red blood cells (RBCs) that can possibly cause harmful effects to recipients. Currently, there was no established guideline available to suggest transfusion of fresher RBCs had any advantages over older RBCs in clinical outcomes...

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Main Author:	Omar, Norkhazarina
Format:	Thesis
Language:	English
Published:	2019
Subjects:	RB37-56.5 Clinical pathology Laboratory technique
Online Access:	http://eprints.usm.my/46645/1/DR.%20NORKHAZARINA%20BINTI%20OMAR_HJ.pdf
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spelling	my-usm-ep.466452020-06-29T07:51:24Z Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang 2019 Omar, Norkhazarina RB37-56.5 Clinical pathology. Laboratory technique Background: Extended storage time lead to storage lesion changes in red blood cells (RBCs) that can possibly cause harmful effects to recipients. Currently, there was no established guideline available to suggest transfusion of fresher RBCs had any advantages over older RBCs in clinical outcomes among cardiac surgical patients. In this study, adverse outcomes in post coronary artery bypass grafting (CABG) patients who received different storage age of RBCs were analysed Methods: This was an observational retrospective study done in Hospital Selayang. Data from patients who underwent CABG within one year were collected. Subjects were allocated into three groups according to the storage age of RBCs that they received; ≤ 14 days, >14 days and mixed. The effect of RBCs storage age on various post-operative outcomes were analysed using multivariable analysis with significant p<0.05. Comparison total unit of RBCs transfused between the three storage ages of RBCs was also studied using One-way ANOVA test. Results: A total of 253 patients who received 954 RBCs units were analysed. Subjects were; n = 62 in group of RBCs ≤ 14 days, n = 99 in group of RBCs >14 days and n = 92 in mixed group. There were no association of any of the groups of RBCs storage ages with post CABG adverse outcomes. Patients transfused with greater unit of RBCs more likely to receive mixed variance storage age of RBCs. Conclusion: The duration of RBCs storage was not associated with significant differences in adverse outcomes among post CABG patients. 2019 Thesis http://eprints.usm.my/46645/ http://eprints.usm.my/46645/1/DR.%20NORKHAZARINA%20BINTI%20OMAR_HJ.pdf application/pdf en public masters Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RB37-56.5 Clinical pathology Laboratory technique
spellingShingle	RB37-56.5 Clinical pathology Laboratory technique Omar, Norkhazarina Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang
description	Background: Extended storage time lead to storage lesion changes in red blood cells (RBCs) that can possibly cause harmful effects to recipients. Currently, there was no established guideline available to suggest transfusion of fresher RBCs had any advantages over older RBCs in clinical outcomes among cardiac surgical patients. In this study, adverse outcomes in post coronary artery bypass grafting (CABG) patients who received different storage age of RBCs were analysed Methods: This was an observational retrospective study done in Hospital Selayang. Data from patients who underwent CABG within one year were collected. Subjects were allocated into three groups according to the storage age of RBCs that they received; ≤ 14 days, >14 days and mixed. The effect of RBCs storage age on various post-operative outcomes were analysed using multivariable analysis with significant p<0.05. Comparison total unit of RBCs transfused between the three storage ages of RBCs was also studied using One-way ANOVA test. Results: A total of 253 patients who received 954 RBCs units were analysed. Subjects were; n = 62 in group of RBCs ≤ 14 days, n = 99 in group of RBCs >14 days and n = 92 in mixed group. There were no association of any of the groups of RBCs storage ages with post CABG adverse outcomes. Patients transfused with greater unit of RBCs more likely to receive mixed variance storage age of RBCs. Conclusion: The duration of RBCs storage was not associated with significant differences in adverse outcomes among post CABG patients.
format	Thesis
qualification_level	Master's degree
author	Omar, Norkhazarina
author_facet	Omar, Norkhazarina
author_sort	Omar, Norkhazarina
title	Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang
title_short	Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang
title_full	Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang
title_fullStr	Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang
title_full_unstemmed	Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang
title_sort	association of the storage age of trasfused rbc with adverse outcomes in post cabg patients at hospital serdang
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2019
url	http://eprints.usm.my/46645/1/DR.%20NORKHAZARINA%20BINTI%20OMAR_HJ.pdf
_version_	1747821703787970560

Association Of The Storage Age Of Trasfused RBC With Adverse Outcomes In Post Cabg Patients At Hospital Serdang

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