Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action

Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 in...

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Main Author:	Varghese, Christapher Parayil
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/47652/1/ANTIHYPERLIPIDEMIC%20ACTIVITY.pdf%20cut.pdf
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id	my-usm-ep.47652
record_format	uketd_dc
spelling	my-usm-ep.476522020-10-21T07:20:08Z Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action 2017-09 Varghese, Christapher Parayil RS1-441 Pharmacy and materia medica Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 induced acute hyperlipidemia in rats. Atorvastatin (60 mg/kg) was used as standard drug. The study showed that both extracts reduced the total cholesterol (TC), triglycerides (TG), LDL, VLDL, atherogenic index, and increased HDL levels when compared with hyperlipidemic control and the effect was higher in methanol extract when compared to aqueous extract. 2017-09 Thesis http://eprints.usm.my/47652/ http://eprints.usm.my/47652/1/ANTIHYPERLIPIDEMIC%20ACTIVITY.pdf%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmacy)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Varghese, Christapher Parayil Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
description	Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 induced acute hyperlipidemia in rats. Atorvastatin (60 mg/kg) was used as standard drug. The study showed that both extracts reduced the total cholesterol (TC), triglycerides (TG), LDL, VLDL, atherogenic index, and increased HDL levels when compared with hyperlipidemic control and the effect was higher in methanol extract when compared to aqueous extract.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Varghese, Christapher Parayil
author_facet	Varghese, Christapher Parayil
author_sort	Varghese, Christapher Parayil
title	Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
title_short	Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
title_full	Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
title_fullStr	Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
title_full_unstemmed	Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
title_sort	antihyperlipidemic activity of polygonum minus and elucidation of its mechanism of action
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi (School of Pharmacy)
publishDate	2017
url	http://eprints.usm.my/47652/1/ANTIHYPERLIPIDEMIC%20ACTIVITY.pdf%20cut.pdf
_version_	1747821814376038400

Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action

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