The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways

The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways

In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells...

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Main Author: Khan, Md Shamsuddin Sultan
Format: Thesis
Language:English
Published: 2017
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/47701/1/THE%20DEVELOPMENT%20OF%20ROSMARINIC%20ACID.pdf%20cut.pdf
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spelling my-usm-ep.477012020-10-22T08:34:47Z The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways 2017-09 Khan, Md Shamsuddin Sultan RS1-441 Pharmacy and materia medica In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells. Antiangiogenic activity was investigated with tube formation, CAM, and aortic explant assays. The compounds’ activity in IL17A and VEGF expression was determined using ELISA and their apoptotic activity was assessed by the Caspase assay. The cancer pathway was determined using the reporter gene assay. 2017-09 Thesis http://eprints.usm.my/47701/ http://eprints.usm.my/47701/1/THE%20DEVELOPMENT%20OF%20ROSMARINIC%20ACID.pdf%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmacy)
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Khan, Md Shamsuddin Sultan
The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
description In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells. Antiangiogenic activity was investigated with tube formation, CAM, and aortic explant assays. The compounds’ activity in IL17A and VEGF expression was determined using ELISA and their apoptotic activity was assessed by the Caspase assay. The cancer pathway was determined using the reporter gene assay.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Khan, Md Shamsuddin Sultan
author_facet Khan, Md Shamsuddin Sultan
author_sort Khan, Md Shamsuddin Sultan
title The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_short The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_full The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_fullStr The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_full_unstemmed The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_sort development of rosmarinic acid derivatives to target il17a in glioblastoma multiforme via angiogenic pathways
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi (School of Pharmacy)
publishDate 2017
url http://eprints.usm.my/47701/1/THE%20DEVELOPMENT%20OF%20ROSMARINIC%20ACID.pdf%20cut.pdf
_version_ 1747821819004452864

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