Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells

Packed Red Blood Cells (PRBC) must be transfused within 30 minutes upon removal from blood refrigerator and the PRBC should not be hold in the ward where the storage temperature is not controlled. Untransfused blood which returned to the blood bank shall be discarded unless it is kept in an appropri...

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主要作者:	Hassan, Noor Hamizah Mohd
格式:	Thesis
语言:	English
出版:	2019
主题:	AC801-895 Inaugural and program dissertations
在线阅读:	http://eprints.usm.my/48143/1/NOOR%20HAMIZAH_hj.pdf
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id	my-usm-ep.48143
record_format	uketd_dc
spelling	my-usm-ep.481432021-01-20T07:09:24Z Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells 2019 Hassan, Noor Hamizah Mohd AC801-895 Inaugural and program dissertations Packed Red Blood Cells (PRBC) must be transfused within 30 minutes upon removal from blood refrigerator and the PRBC should not be hold in the ward where the storage temperature is not controlled. Untransfused blood which returned to the blood bank shall be discarded unless it is kept in an appropriate condition and temperature. Intermittent storage outside allowable temperature range often leads to destruction of the PRBC unit. This was a cross sectional study performed to determine the PRBC warming rates and the quality of PRBC upon repetitive exposure to uncontrolled temperature after 30 minutes and 4 hours. In this study four PRBC units (228 mL ± 37mL) collected from eligible volunteer subjects were equivalently split into two units, producing eight smaller units PRBC (±130mL) which then assigned into two groups; control and experimental group. Eight units of PRBC from both control and experimental group were tested on day 1, day 7, day 14 and day 35 of storage for haemoglobin level, haematocrit, haemolysis rate, potassium, lactate dehydrogenase (LDH), pH and sterility. The PRBC warming rate upon exposure to uncontrolled temperature were monitored and recorded. All PRBCs achieved desired quality requirement from national guideline from day 1 to day 35 for haematocrit, haemolysis rate, and sterility. However, none of the PRBC units met the standard requirement (>45g/unit) for haemoglobin starting day 14 to day 35. No significant changes observed for all PRBC’s quality over repetitive exposure to uncontrolled temperature in 35 days in experimental group (P<0.05). There was also no evidence of bacterial contamination in PRBC at the end of their shelf life. 2019 Thesis http://eprints.usm.my/48143/ http://eprints.usm.my/48143/1/NOOR%20HAMIZAH_hj.pdf application/pdf en public masters Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	AC801-895 Inaugural and program dissertations
spellingShingle	AC801-895 Inaugural and program dissertations Hassan, Noor Hamizah Mohd Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells
description	Packed Red Blood Cells (PRBC) must be transfused within 30 minutes upon removal from blood refrigerator and the PRBC should not be hold in the ward where the storage temperature is not controlled. Untransfused blood which returned to the blood bank shall be discarded unless it is kept in an appropriate condition and temperature. Intermittent storage outside allowable temperature range often leads to destruction of the PRBC unit. This was a cross sectional study performed to determine the PRBC warming rates and the quality of PRBC upon repetitive exposure to uncontrolled temperature after 30 minutes and 4 hours. In this study four PRBC units (228 mL ± 37mL) collected from eligible volunteer subjects were equivalently split into two units, producing eight smaller units PRBC (±130mL) which then assigned into two groups; control and experimental group. Eight units of PRBC from both control and experimental group were tested on day 1, day 7, day 14 and day 35 of storage for haemoglobin level, haematocrit, haemolysis rate, potassium, lactate dehydrogenase (LDH), pH and sterility. The PRBC warming rate upon exposure to uncontrolled temperature were monitored and recorded. All PRBCs achieved desired quality requirement from national guideline from day 1 to day 35 for haematocrit, haemolysis rate, and sterility. However, none of the PRBC units met the standard requirement (>45g/unit) for haemoglobin starting day 14 to day 35. No significant changes observed for all PRBC’s quality over repetitive exposure to uncontrolled temperature in 35 days in experimental group (P<0.05). There was also no evidence of bacterial contamination in PRBC at the end of their shelf life.
format	Thesis
qualification_level	Master's degree
author	Hassan, Noor Hamizah Mohd
author_facet	Hassan, Noor Hamizah Mohd
author_sort	Hassan, Noor Hamizah Mohd
title	Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells
title_short	Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells
title_full	Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells
title_fullStr	Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells
title_full_unstemmed	Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells
title_sort	effects of repetitive uncontrolled temperature exposure on the quality of packed red blood cells
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2019
url	http://eprints.usm.my/48143/1/NOOR%20HAMIZAH_hj.pdf
_version_	1747821887610683392

Effects Of Repetitive Uncontrolled Temperature Exposure On The Quality Of Packed Red Blood Cells

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