Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life

Lower urinary tract symptoms (LUTS) include all urological symptoms related to voiding, storage and post-micturition, which are associated with great emotional distress to sufferers and high economic burden to the society. The development of LUTS is deemed to be associated with certain medications a...

Full description

Saved in:

Bibliographic Details
Main Author:	Salman, Muhammad
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/48196/1/Muhammad%20Salman%20cut.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.48196
record_format	uketd_dc
spelling	my-usm-ep.481962021-01-26T03:32:08Z Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life 2018-12 Salman, Muhammad RS1-441 Pharmacy and materia medica Lower urinary tract symptoms (LUTS) include all urological symptoms related to voiding, storage and post-micturition, which are associated with great emotional distress to sufferers and high economic burden to the society. The development of LUTS is deemed to be associated with certain medications and diseases. Among the former, calcium channel blockers (CCBs) are believed to be involved in development or worsening of LUTS, however, information concerning such correlation is sparse. Therefore, the present study was designed to investigate the effects of CCBs on LUTS and its impact on patients‘ sleep pattern, depression and quality of life (QOL). This study was carried out in 2 phases; Phase-I included a psychometric validation study wherein the International Prostate Symptom Score-Urdu (IPSS-Urdu) was developed and validated, whereas Phase-II was a cross-sectional study to evaluate the effect of CCB mono- and combined-therapy on LUTS. IPSS-Urdu was developed by a two-step forward and back translation, and evaluated for its psychometric properties in a prospective study involving patients (n = 267) suffering from LUTS, conducted at the Outpatient Urology Department, Mayo Hospital, Lahore, Pakistan. Overall reliability of IPSS-Urdu was satisfactory [Cronbach‘s alpha = 0.72, Intra-Class Correlation Coefficient (ICC) of symptom-questions = 0.92 and ICC of QOL index = 0.75]. Exploratory factor analysis revealed that two factors were consistent, which together explained 59.8% of the variance. Confirmatory factor analysis further showed two-factor model, with acceptable fitting patterns. 2018-12 Thesis http://eprints.usm.my/48196/ http://eprints.usm.my/48196/1/Muhammad%20Salman%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Salman, Muhammad Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life
description	Lower urinary tract symptoms (LUTS) include all urological symptoms related to voiding, storage and post-micturition, which are associated with great emotional distress to sufferers and high economic burden to the society. The development of LUTS is deemed to be associated with certain medications and diseases. Among the former, calcium channel blockers (CCBs) are believed to be involved in development or worsening of LUTS, however, information concerning such correlation is sparse. Therefore, the present study was designed to investigate the effects of CCBs on LUTS and its impact on patients‘ sleep pattern, depression and quality of life (QOL). This study was carried out in 2 phases; Phase-I included a psychometric validation study wherein the International Prostate Symptom Score-Urdu (IPSS-Urdu) was developed and validated, whereas Phase-II was a cross-sectional study to evaluate the effect of CCB mono- and combined-therapy on LUTS. IPSS-Urdu was developed by a two-step forward and back translation, and evaluated for its psychometric properties in a prospective study involving patients (n = 267) suffering from LUTS, conducted at the Outpatient Urology Department, Mayo Hospital, Lahore, Pakistan. Overall reliability of IPSS-Urdu was satisfactory [Cronbach‘s alpha = 0.72, Intra-Class Correlation Coefficient (ICC) of symptom-questions = 0.92 and ICC of QOL index = 0.75]. Exploratory factor analysis revealed that two factors were consistent, which together explained 59.8% of the variance. Confirmatory factor analysis further showed two-factor model, with acceptable fitting patterns.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Salman, Muhammad
author_facet	Salman, Muhammad
author_sort	Salman, Muhammad
title	Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life
title_short	Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life
title_full	Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life
title_fullStr	Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life
title_full_unstemmed	Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life
title_sort	effect of calcium channel blocker with other antihypertensive agents on lower urinary tract symptoms and its impact on patients’ quality of life
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2018
url	http://eprints.usm.my/48196/1/Muhammad%20Salman%20cut.pdf
_version_	1747821899121950720

Effect Of Calcium Channel Blocker With Other Antihypertensive Agents On Lower Urinary Tract Symptoms And Its Impact On Patients’ Quality Of Life

Similar Items