Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism

Trauma and prolonged immobilization induce hypercoagulable state with thrombotic potential. Multiple studies have shown close relationship between haematological, haemostatic & inflammatory markers and post traumatic patients. The aims of this study were to investigate the changes of hypercoa...

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Main Author:	Iberahim, Salfarina
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC666-701 Diseases of the circulatory (Cardiovascular) system
Online Access:	http://eprints.usm.my/48215/1/Dr.%20Salfarina%20Iberahim-24%20pages.pdf
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id	my-usm-ep.48215
record_format	uketd_dc
spelling	my-usm-ep.482152021-01-31T07:03:37Z Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism 2018 Iberahim, Salfarina RC666-701 Diseases of the circulatory (Cardiovascular) system Trauma and prolonged immobilization induce hypercoagulable state with thrombotic potential. Multiple studies have shown close relationship between haematological, haemostatic & inflammatory markers and post traumatic patients. The aims of this study were to investigate the changes of hypercoagulable markers (haemostatic, inflammatory and haematological parameters) in prolonged immobilized trauma patients and to determine the correlation between haemostatic parameters and inflammatory parameters (ESR, CRP) among the subjects. The association between clinical risk factors (age, sex, BMI, smoking and type of injury) and the abnormal laboratory parameters were also studied including the relationship with VTE. A prospective cohort study was conducted at Hospital University Sains Malaysia from September 2016 to July 2017. A total of 52 patients with lower limb/s fracture with age ranged from 12 to 59 years old, who required immobilization more than 7 days and received no anticoagulant prophylaxis were involved in this study. The predetermined parameters were serially measured on day 1 and day 8 of immobilization. The laboratory tests included PT, aPTT, D-dimer, Fibrinogen, AT, Protein C, Protein S, ESR, CRP and platelet count. Subjects’ characteristic and clinical risk factors (age, sex, BMI, smoking and type of injury) were recorded. 2018 Thesis http://eprints.usm.my/48215/ http://eprints.usm.my/48215/1/Dr.%20Salfarina%20Iberahim-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC666-701 Diseases of the circulatory (Cardiovascular) system
spellingShingle	RC666-701 Diseases of the circulatory (Cardiovascular) system Iberahim, Salfarina Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism
description	Trauma and prolonged immobilization induce hypercoagulable state with thrombotic potential. Multiple studies have shown close relationship between haematological, haemostatic & inflammatory markers and post traumatic patients. The aims of this study were to investigate the changes of hypercoagulable markers (haemostatic, inflammatory and haematological parameters) in prolonged immobilized trauma patients and to determine the correlation between haemostatic parameters and inflammatory parameters (ESR, CRP) among the subjects. The association between clinical risk factors (age, sex, BMI, smoking and type of injury) and the abnormal laboratory parameters were also studied including the relationship with VTE. A prospective cohort study was conducted at Hospital University Sains Malaysia from September 2016 to July 2017. A total of 52 patients with lower limb/s fracture with age ranged from 12 to 59 years old, who required immobilization more than 7 days and received no anticoagulant prophylaxis were involved in this study. The predetermined parameters were serially measured on day 1 and day 8 of immobilization. The laboratory tests included PT, aPTT, D-dimer, Fibrinogen, AT, Protein C, Protein S, ESR, CRP and platelet count. Subjects’ characteristic and clinical risk factors (age, sex, BMI, smoking and type of injury) were recorded.
format	Thesis
qualification_level	Master's degree
author	Iberahim, Salfarina
author_facet	Iberahim, Salfarina
author_sort	Iberahim, Salfarina
title	Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism
title_short	Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism
title_full	Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism
title_fullStr	Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism
title_full_unstemmed	Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism
title_sort	haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/48215/1/Dr.%20Salfarina%20Iberahim-24%20pages.pdf
_version_	1747821903551135744

Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism

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