Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time

Purpose: To look into cut off value for earlier discrimination between transient and permanent hypothyroidism, to determine median time for thyroid function to normalize upon cessation of treatment in transient group and its affecting factors. Method: 55 cases of congenital hypothyroidism were iden...

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Main Author:	Hamid, Siti Hazlini Abdul Hamid
Format:	Thesis
Language:	English
Published:	2018
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/48424/1/Dr.%20Siti%20Hazlini%20Abdul%20Hamid-24%20pages.pdf
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spelling	my-usm-ep.484242021-02-24T03:41:31Z Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time 2018 Hamid, Siti Hazlini Abdul Hamid R Medicine Purpose: To look into cut off value for earlier discrimination between transient and permanent hypothyroidism, to determine median time for thyroid function to normalize upon cessation of treatment in transient group and its affecting factors. Method: 55 cases of congenital hypothyroidism were identified from retrospective record reviews. 37 cases were with permanent hypothyroidism and 18 cases were with transient hypothyroidism. The optimal cut off value of initial thyroid stimulating hormone (TSH) and free thyroxine (FT4) level were analyzed using receiver operating characteristics (ROC) curve analysis for both groups. Kaplan-Meier survival analysis was conducted to estimate median time for thyroid function to normalize within the transient hypothyroidism group. The log-rank test was used to determine factors affecting the median time. Results: The cut off value for initial TSH within transient hypothyroidism group was 13.55 mIU/L with area under ROC curve of 68.9 % (sensitivity 58.8 %, specificity 73.5%) and the initial free T4 was 13.45 pmol/L with area under ROC curve of 71 % (sensitivity 70.6 %, specificity 64.7%). The median time obtained was about 8 weeks and there were no significant affecting factors identified. Conclusion: Transient hypothyroid infants’ initial TSH was lower compared to permanent group and it takes 2 months for thyroid function to normalized. 2018 Thesis http://eprints.usm.my/48424/ http://eprints.usm.my/48424/1/Dr.%20Siti%20Hazlini%20Abdul%20Hamid-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Hamid, Siti Hazlini Abdul Hamid Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time
description	Purpose: To look into cut off value for earlier discrimination between transient and permanent hypothyroidism, to determine median time for thyroid function to normalize upon cessation of treatment in transient group and its affecting factors. Method: 55 cases of congenital hypothyroidism were identified from retrospective record reviews. 37 cases were with permanent hypothyroidism and 18 cases were with transient hypothyroidism. The optimal cut off value of initial thyroid stimulating hormone (TSH) and free thyroxine (FT4) level were analyzed using receiver operating characteristics (ROC) curve analysis for both groups. Kaplan-Meier survival analysis was conducted to estimate median time for thyroid function to normalize within the transient hypothyroidism group. The log-rank test was used to determine factors affecting the median time. Results: The cut off value for initial TSH within transient hypothyroidism group was 13.55 mIU/L with area under ROC curve of 68.9 % (sensitivity 58.8 %, specificity 73.5%) and the initial free T4 was 13.45 pmol/L with area under ROC curve of 71 % (sensitivity 70.6 %, specificity 64.7%). The median time obtained was about 8 weeks and there were no significant affecting factors identified. Conclusion: Transient hypothyroid infants’ initial TSH was lower compared to permanent group and it takes 2 months for thyroid function to normalized.
format	Thesis
qualification_level	Master's degree
author	Hamid, Siti Hazlini Abdul Hamid
author_facet	Hamid, Siti Hazlini Abdul Hamid
author_sort	Hamid, Siti Hazlini Abdul Hamid
title	Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time
title_short	Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time
title_full	Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time
title_fullStr	Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time
title_full_unstemmed	Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time
title_sort	transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/48424/1/Dr.%20Siti%20Hazlini%20Abdul%20Hamid-24%20pages.pdf
_version_	1747821931825987584

Transient congenital hypothyroidism : cut off value for diagnosis, median time for normalization of thyroid function and factors affecting the median time

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