The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis

Colorectal cancer, which is the cancer that develops in the colon or rectum, is one of the most common cancers that lead to death. The prevalence of colorectal cancer in Malaysia is expected to increase due to the aging population, socioeconomic advances, and increasingly Westernised diet and lifest...

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Main Author:	Bronwyn, Lok
Format:	Thesis
Language:	English
Published:	2019
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/48683/1/BRONWYN%20LOK24.pdf
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id	my-usm-ep.48683
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spelling	my-usm-ep.486832021-03-23T12:40:31Z The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis 2019-05 Bronwyn, Lok RS1-441 Pharmacy and materia medica Colorectal cancer, which is the cancer that develops in the colon or rectum, is one of the most common cancers that lead to death. The prevalence of colorectal cancer in Malaysia is expected to increase due to the aging population, socioeconomic advances, and increasingly Westernised diet and lifestyle. The growth of colorectal tumours beyond a certain size, as well as their metastatic spread, is dependent on the increase in angiogenesis of their surrounding vasculature. As Psidium guajava (guava) leaves are rich in phenolic compounds, flavonoids, carotenoids, and vitamins, the anti-angiogenic and anticancer activities of P. guajava leaf extracts were investigated to assess their potential in the treatment of the angiogenesis-dependent colorectal cancer. Three extracts were produced using distilled water, ethanol, and n-hexane as solvents, and were labelled as dH2O, EOH, and NH. The extracts were physically characterised through gas chromatography–mass spectrometry (GC-MS), ultraviolet-visible spectroscopy (UV-Vis), and Fourier transform infrared spectroscopy (FTIR). Through the DPPH radical scavenging, total phenolic content, and total flavonoid content assays, the EOH extract was found to have the highest antioxidant activity. The dH2O and EOH extracts exhibited more inhibitory activity against EA.hy926 (human vascular endothelial) cell viability and microvessel growth from rat aortic rings compared to the NH extract, indicating a better anti-angiogenic activity. 2019-05 Thesis http://eprints.usm.my/48683/ http://eprints.usm.my/48683/1/BRONWYN%20LOK24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Bronwyn, Lok The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis
description	Colorectal cancer, which is the cancer that develops in the colon or rectum, is one of the most common cancers that lead to death. The prevalence of colorectal cancer in Malaysia is expected to increase due to the aging population, socioeconomic advances, and increasingly Westernised diet and lifestyle. The growth of colorectal tumours beyond a certain size, as well as their metastatic spread, is dependent on the increase in angiogenesis of their surrounding vasculature. As Psidium guajava (guava) leaves are rich in phenolic compounds, flavonoids, carotenoids, and vitamins, the anti-angiogenic and anticancer activities of P. guajava leaf extracts were investigated to assess their potential in the treatment of the angiogenesis-dependent colorectal cancer. Three extracts were produced using distilled water, ethanol, and n-hexane as solvents, and were labelled as dH2O, EOH, and NH. The extracts were physically characterised through gas chromatography–mass spectrometry (GC-MS), ultraviolet-visible spectroscopy (UV-Vis), and Fourier transform infrared spectroscopy (FTIR). Through the DPPH radical scavenging, total phenolic content, and total flavonoid content assays, the EOH extract was found to have the highest antioxidant activity. The dH2O and EOH extracts exhibited more inhibitory activity against EA.hy926 (human vascular endothelial) cell viability and microvessel growth from rat aortic rings compared to the NH extract, indicating a better anti-angiogenic activity.
format	Thesis
qualification_level	Master's degree
author	Bronwyn, Lok
author_facet	Bronwyn, Lok
author_sort	Bronwyn, Lok
title	The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis
title_short	The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis
title_full	The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis
title_fullStr	The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis
title_full_unstemmed	The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis
title_sort	potential anti-cancer effects of psidium guajava (guava) leaves on coloretal cancer via the inhibition of angiogenesis
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2019
url	http://eprints.usm.my/48683/1/BRONWYN%20LOK24.pdf
_version_	1747821961138929664

The Potential Anti-Cancer Effects Of Psidium Guajava (Guava) Leaves On Coloretal Cancer Via The Inhibition Of Angiogenesis

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