The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment

The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment

Parkinson's disease (PD) is widely known as a 'motor' disease, but it also has several non-motor features including cognitive impairment. Cognitive impairment has significant impacts on several aspects of PD. There is as yet a study on cognitive impairment and PD done involving our...

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Main Author: Hilmi, Abdullah
Format: Thesis
Language:English
Published: 2007
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/48756/1/DR.%20HILMI%20BIN%20ABDULLAH%20-%2024%20pages.pdf
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spelling my-usm-ep.487562021-04-04T01:38:27Z The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment 2007 Hilmi, Abdullah R Medicine (General) Parkinson's disease (PD) is widely known as a 'motor' disease, but it also has several non-motor features including cognitive impairment. Cognitive impairment has significant impacts on several aspects of PD. There is as yet a study on cognitive impairment and PD done involving our population. Objectives: To compare the Unified Parkinson's Disease Rating Scale (UPDRS) score between PD patients with and without cognitive impairment. Secondly, to determine the prevalence of cognitive impairment in patients with PD under Hospital Universiti Sains Malaysia (HUSM) follow-up. Methods: This was a cross-sectional study done at the HUSM Neurology Clinic, beginning from June till November 2006. Eighty PD patients who satisfied the study criteria were recruited into the study. Their cognitive status was assessed using the validated Malay version of the Mini-Mental State Examination (MMSE). A score of :S 24/30 signified presence of cognitive impairment while> 24/30 was normal. Regardless of their MMSE scores, all the patients then underwent assessment using the UPDRS. The UPDRS contains four items i.e. mentation, behaviour, and mood; activities of daily living; motor examination; and complications of therapy. Scores were taken from each item, and they were then totaled to obtain a total score. The study protocol was reviewed and approved by the USM Ethics and Research Committee. Results: Thirty two patients (40%) had cognitive impairment, ranging from mild to severe, based on the MMSE. Patients with cognitive impairment had significantly worse scores for each UPDRS item compared to the non-cognitive impairment group (p < 0.05). They also had worse rigidity and bradykinesia compared to the other group (p < 0.05). After adjusting for potential confounders e.g. age and disease duration, the cognitive impairment group still performed worse in the UPDRS assessment (p < 0.05). Conclusions: The study showed that the presence of cognitive impairment resulted in worse UPDRS scores. There was a high prevalence of cognitive impairment in PD patients under HUSM follow-up. Therefore, PD patients should be routinely screened for cognitive impairment. 2007 Thesis http://eprints.usm.my/48756/ http://eprints.usm.my/48756/1/DR.%20HILMI%20BIN%20ABDULLAH%20-%2024%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Hilmi, Abdullah
The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment
description Parkinson's disease (PD) is widely known as a 'motor' disease, but it also has several non-motor features including cognitive impairment. Cognitive impairment has significant impacts on several aspects of PD. There is as yet a study on cognitive impairment and PD done involving our population. Objectives: To compare the Unified Parkinson's Disease Rating Scale (UPDRS) score between PD patients with and without cognitive impairment. Secondly, to determine the prevalence of cognitive impairment in patients with PD under Hospital Universiti Sains Malaysia (HUSM) follow-up. Methods: This was a cross-sectional study done at the HUSM Neurology Clinic, beginning from June till November 2006. Eighty PD patients who satisfied the study criteria were recruited into the study. Their cognitive status was assessed using the validated Malay version of the Mini-Mental State Examination (MMSE). A score of :S 24/30 signified presence of cognitive impairment while> 24/30 was normal. Regardless of their MMSE scores, all the patients then underwent assessment using the UPDRS. The UPDRS contains four items i.e. mentation, behaviour, and mood; activities of daily living; motor examination; and complications of therapy. Scores were taken from each item, and they were then totaled to obtain a total score. The study protocol was reviewed and approved by the USM Ethics and Research Committee. Results: Thirty two patients (40%) had cognitive impairment, ranging from mild to severe, based on the MMSE. Patients with cognitive impairment had significantly worse scores for each UPDRS item compared to the non-cognitive impairment group (p < 0.05). They also had worse rigidity and bradykinesia compared to the other group (p < 0.05). After adjusting for potential confounders e.g. age and disease duration, the cognitive impairment group still performed worse in the UPDRS assessment (p < 0.05). Conclusions: The study showed that the presence of cognitive impairment resulted in worse UPDRS scores. There was a high prevalence of cognitive impairment in PD patients under HUSM follow-up. Therefore, PD patients should be routinely screened for cognitive impairment.
format Thesis
qualification_level Master's degree
author Hilmi, Abdullah
author_facet Hilmi, Abdullah
author_sort Hilmi, Abdullah
title The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment
title_short The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment
title_full The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment
title_fullStr The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment
title_full_unstemmed The unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment
title_sort unified parkinson's disease rating scale score in parkinson's disease patients with and without cognitive impairment
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2007
url http://eprints.usm.my/48756/1/DR.%20HILMI%20BIN%20ABDULLAH%20-%2024%20pages.pdf
_version_ 1747821966055702528

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