Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study

Intubation with Glidescope Videolaryngoscope (GSVL) has been associated with longer period of pressor response. This study aimed to look at haemodynamic parameters (SBP, DBP, HR, MAP) during laryngoscopy and intubation using GSVL with either Lignocaine or Magnesium used to attenuate the pressor r...

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Main Author:	Ahmad Afifi, Mohd Arshad
Format:	Thesis
Language:	English
Published:	2010
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/51481/1/AHMAD%20AFIFI%20MOHD%20ARSHAD%20-%2024%20pages.pdf
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spelling	my-usm-ep.514812022-12-21T08:03:05Z Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study 2010 Ahmad Afifi, Mohd Arshad R Medicine (General) Intubation with Glidescope Videolaryngoscope (GSVL) has been associated with longer period of pressor response. This study aimed to look at haemodynamic parameters (SBP, DBP, HR, MAP) during laryngoscopy and intubation using GSVL with either Lignocaine or Magnesium used to attenuate the pressor response. Methodology: 82 patients planned for general anesthesia with endotracheal intubation were recruited. They were blinded, and randomized into 2 groups; Lignocaine (A) and Magnesium (B). The agents were given at 1.5mg/kg and 40mg/kg respectively in group A and B, and each diluted into 20ml syringe and given IV over 5min before induction. Inductions were standardized with IV Propofol 2mg/kg, IV Fentanyl Imcg/kg and IV Rocuronium 1 mg/kg. A single intubator with experience in GSVL performed the intubations. Haemodynamic parameters were collected at baseline, post induction, at intubation, 1, 3, 5 and 10 minutes post intubation. The interaction of haemodynamic parameters within and between groups were tested with repeated measure ANCOVA. Result: There were significant interaction between time during intubation and estimated marginal mean of DBP, MAP and HR in both groups (p<0.05). The changes in estimated mean DBP and MAP were constantly less than baseline value post induction and intubation. However the rise in HR at Imin postintubation in Magnesium group was 11% above baseline and required 5 minutes to return to baseline (p<0.05). The interaction in SBP is not significant (p>0.05). XV Conclusion: Magnesium at 40mg/kg is less effective than lignocaine in attenuating pressor response to intubation with GSVL. XVI Universiti Sains Malaysia 2010 Thesis http://eprints.usm.my/51481/ http://eprints.usm.my/51481/1/AHMAD%20AFIFI%20MOHD%20ARSHAD%20-%2024%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Ahmad Afifi, Mohd Arshad Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study
description	Intubation with Glidescope Videolaryngoscope (GSVL) has been associated with longer period of pressor response. This study aimed to look at haemodynamic parameters (SBP, DBP, HR, MAP) during laryngoscopy and intubation using GSVL with either Lignocaine or Magnesium used to attenuate the pressor response. Methodology: 82 patients planned for general anesthesia with endotracheal intubation were recruited. They were blinded, and randomized into 2 groups; Lignocaine (A) and Magnesium (B). The agents were given at 1.5mg/kg and 40mg/kg respectively in group A and B, and each diluted into 20ml syringe and given IV over 5min before induction. Inductions were standardized with IV Propofol 2mg/kg, IV Fentanyl Imcg/kg and IV Rocuronium 1 mg/kg. A single intubator with experience in GSVL performed the intubations. Haemodynamic parameters were collected at baseline, post induction, at intubation, 1, 3, 5 and 10 minutes post intubation. The interaction of haemodynamic parameters within and between groups were tested with repeated measure ANCOVA. Result: There were significant interaction between time during intubation and estimated marginal mean of DBP, MAP and HR in both groups (p<0.05). The changes in estimated mean DBP and MAP were constantly less than baseline value post induction and intubation. However the rise in HR at Imin postintubation in Magnesium group was 11% above baseline and required 5 minutes to return to baseline (p<0.05). The interaction in SBP is not significant (p>0.05). XV Conclusion: Magnesium at 40mg/kg is less effective than lignocaine in attenuating pressor response to intubation with GSVL. XVI
format	Thesis
qualification_level	Master's degree
author	Ahmad Afifi, Mohd Arshad
author_facet	Ahmad Afifi, Mohd Arshad
author_sort	Ahmad Afifi, Mohd Arshad
title	Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study
title_short	Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study
title_full	Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study
title_fullStr	Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study
title_full_unstemmed	Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study
title_sort	attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2010
url	http://eprints.usm.my/51481/1/AHMAD%20AFIFI%20MOHD%20ARSHAD%20-%2024%20pages.pdf
_version_	1776101084870213632

Attenuation of haemodynamic response during intubation with glidescope® video laryngoscope using either lignocaine or magnesium; a randomized clinical study

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