The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway

Angiogenesis is a process of new blood vessel development which can be triggered by inflammation. Both processes play crucial role in colorectal cancer. Natural products that have high level of antioxidants are known to have anti-inflammatory and anti-angiogenic activity and hence could be useful to...

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Main Author:	Al Deeb, Ibrahim Deeb Tawfiq
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RC254-282 Neoplasms Tumors Oncology (including Cancer)
Online Access:	http://eprints.usm.my/51920/1/IBRAHIM%20DEEB%20TAWFIQ%20AL%20DEEB%20-%20TESIS.pdf
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id	my-usm-ep.51920
record_format	uketd_dc
spelling	my-usm-ep.519202022-03-14T03:32:19Z The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway 2021-03 Al Deeb, Ibrahim Deeb Tawfiq RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Angiogenesis is a process of new blood vessel development which can be triggered by inflammation. Both processes play crucial role in colorectal cancer. Natural products that have high level of antioxidants are known to have anti-inflammatory and anti-angiogenic activity and hence could be useful to treat colon cancer. In this work present here, methanolic extracts of 19 plant species of lamiaceae family found in Saudi Arabia were screened for their anti-angiogenic activity to ascertain their potency towards colon cancer. Only six extracts inhibited neovascularization formation by 50% or more, namely Thymbra capitate (Arial part) (97.93±2.63%), Premna resinosa (Stem) (85.03±16.84%), Phlomis viscosa Poir (Arial part) (81.47±22.95%), Salvia samuelssonii (Arial part) (55.69±12.72%), Ocimum basilicum (Leaves) (54.55 ± 4.27%) and Ocimum basilicum (Arial part) (53.99 ± 8.75%). However, methanolic extract of Ocimum basilicum (OB) leaves shown the highest inhibition towards endothelial cells proliferation and migration among other extracts. (OB) leaves were extracted with 70% ethanol (OBL70) at 55 ⁰C, causing a 43% increase in the anti-angiogenic properties compared to methanolic extract. OBL70 was studied in vitro against endothelial cells proliferation, cytotoxicity, migration, invasion and capillary-like structures using MTT, colony formation, scratch, invasion and tube formation assays, respectively. 2021-03 Thesis http://eprints.usm.my/51920/ http://eprints.usm.my/51920/1/IBRAHIM%20DEEB%20TAWFIQ%20AL%20DEEB%20-%20TESIS.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC254-282 Neoplasms Tumors Oncology (including Cancer)
spellingShingle	RC254-282 Neoplasms Tumors Oncology (including Cancer) Al Deeb, Ibrahim Deeb Tawfiq The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway
description	Angiogenesis is a process of new blood vessel development which can be triggered by inflammation. Both processes play crucial role in colorectal cancer. Natural products that have high level of antioxidants are known to have anti-inflammatory and anti-angiogenic activity and hence could be useful to treat colon cancer. In this work present here, methanolic extracts of 19 plant species of lamiaceae family found in Saudi Arabia were screened for their anti-angiogenic activity to ascertain their potency towards colon cancer. Only six extracts inhibited neovascularization formation by 50% or more, namely Thymbra capitate (Arial part) (97.93±2.63%), Premna resinosa (Stem) (85.03±16.84%), Phlomis viscosa Poir (Arial part) (81.47±22.95%), Salvia samuelssonii (Arial part) (55.69±12.72%), Ocimum basilicum (Leaves) (54.55 ± 4.27%) and Ocimum basilicum (Arial part) (53.99 ± 8.75%). However, methanolic extract of Ocimum basilicum (OB) leaves shown the highest inhibition towards endothelial cells proliferation and migration among other extracts. (OB) leaves were extracted with 70% ethanol (OBL70) at 55 ⁰C, causing a 43% increase in the anti-angiogenic properties compared to methanolic extract. OBL70 was studied in vitro against endothelial cells proliferation, cytotoxicity, migration, invasion and capillary-like structures using MTT, colony formation, scratch, invasion and tube formation assays, respectively.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Al Deeb, Ibrahim Deeb Tawfiq
author_facet	Al Deeb, Ibrahim Deeb Tawfiq
author_sort	Al Deeb, Ibrahim Deeb Tawfiq
title	The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway
title_short	The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway
title_full	The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway
title_fullStr	The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway
title_full_unstemmed	The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway
title_sort	potential anti-tumor extract of ocimum basilicum lamiaceae towards colorectal cancer via the angiogenesis mechanistic pathway
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2021
url	http://eprints.usm.my/51920/1/IBRAHIM%20DEEB%20TAWFIQ%20AL%20DEEB%20-%20TESIS.pdf
_version_	1747822113954201600

The Potential Anti-Tumor Extract Of Ocimum Basilicum Lamiaceae Towards Colorectal Cancer Via The Angiogenesis Mechanistic Pathway

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