Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia

Thalassaemia is a common genetic disorder in Malaysia where the mainstay of supportive treatment is regular blood transfusion accompanied with iron-chelating therapy (ICT). Transfusion dependent thalassaemia (TDT) is defines as patient who requires blood transfusion >100mL/Kg annually. There are...

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Main Author:	Wong, Jacqueline Hui Yi
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/51934/1/JACQUELINE%20WONG%20HUI%20YI%20-%20TESIS.pdf
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id	my-usm-ep.51934
record_format	uketd_dc
spelling	my-usm-ep.519342022-03-15T08:12:45Z Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia 2020-11 Wong, Jacqueline Hui Yi RS1-441 Pharmacy and materia medica Thalassaemia is a common genetic disorder in Malaysia where the mainstay of supportive treatment is regular blood transfusion accompanied with iron-chelating therapy (ICT). Transfusion dependent thalassaemia (TDT) is defines as patient who requires blood transfusion >100mL/Kg annually. There are about 4500 patients in Malaysia who are suffering from TDT, however limited data is available on economic burden of this disease and also the efficiency of new formulated Deferasirox (Exjade FCT). Therefore, this study is designed to determine the economic burden of disease, cost effectiveness and budget impact of Exjade FCT in Malaysian context. Substudy one is to estimate the total lifetime cost of a TDT patient. Lifetime healthcare cost (TC2) was simulated using Markov model. Lifetime patient and family healthcare expenditure (TC3) was estimated through cross-sectional health survey approach. Survey was conducted using two-stage sampling method in 13 thalassaemia centers covering all regions in Malaysia. Total lifetime TDT cost (TC1) = TC2 + TC3. Substudy two to evaluate the cost effectiveness of Exjade FCT over the long standing gold standard treatment in TDT – Desferrioxamine. Costs and health outcome (quality adjusted life years) was estimated using Markov model. Costs data was extracted from local database and quality of life data was collected using EQ-5D-3L questionnaire among local thalassaemia patient. Lastly, substudy three, budget impact of converting the current oral ICT- Deferasirox dispersible tablet (Exjade DT) to Exjade FCT was evaluated using budget impact model. 2020-11 Thesis http://eprints.usm.my/51934/ http://eprints.usm.my/51934/1/JACQUELINE%20WONG%20HUI%20YI%20-%20TESIS.pdf application/pdf en public masters Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Wong, Jacqueline Hui Yi Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia
description	Thalassaemia is a common genetic disorder in Malaysia where the mainstay of supportive treatment is regular blood transfusion accompanied with iron-chelating therapy (ICT). Transfusion dependent thalassaemia (TDT) is defines as patient who requires blood transfusion >100mL/Kg annually. There are about 4500 patients in Malaysia who are suffering from TDT, however limited data is available on economic burden of this disease and also the efficiency of new formulated Deferasirox (Exjade FCT). Therefore, this study is designed to determine the economic burden of disease, cost effectiveness and budget impact of Exjade FCT in Malaysian context. Substudy one is to estimate the total lifetime cost of a TDT patient. Lifetime healthcare cost (TC2) was simulated using Markov model. Lifetime patient and family healthcare expenditure (TC3) was estimated through cross-sectional health survey approach. Survey was conducted using two-stage sampling method in 13 thalassaemia centers covering all regions in Malaysia. Total lifetime TDT cost (TC1) = TC2 + TC3. Substudy two to evaluate the cost effectiveness of Exjade FCT over the long standing gold standard treatment in TDT – Desferrioxamine. Costs and health outcome (quality adjusted life years) was estimated using Markov model. Costs data was extracted from local database and quality of life data was collected using EQ-5D-3L questionnaire among local thalassaemia patient. Lastly, substudy three, budget impact of converting the current oral ICT- Deferasirox dispersible tablet (Exjade DT) to Exjade FCT was evaluated using budget impact model.
format	Thesis
qualification_level	Master's degree
author	Wong, Jacqueline Hui Yi
author_facet	Wong, Jacqueline Hui Yi
author_sort	Wong, Jacqueline Hui Yi
title	Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia
title_short	Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia
title_full	Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia
title_fullStr	Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia
title_full_unstemmed	Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia
title_sort	economic analysis of transfusion dependent thalassaemia (tdt) and deferasirox fct efficiency in malaysia
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2020
url	http://eprints.usm.my/51934/1/JACQUELINE%20WONG%20HUI%20YI%20-%20TESIS.pdf
_version_	1747822115163209728

Economic Analysis Of Transfusion Dependent Thalassaemia (Tdt) And Deferasirox Fct Efficiency In Malaysia

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